From: Analysis of porcine body size variation using re-sequencing data of miniature and large pigs
Gene name | Function | Reference |
---|---|---|
ACACB | Downregulated by TGFB1; influencing type-II-diabetes; obesity and lipid metabolism | |
ACOT4 | Linked to FGF21 in mice | Muise et al. [89] |
ADAMTS12 | Blocks Ras/ MAPK pathway | Llamazares et al. [90] |
COMT | Reduced birth weight in humans | Sata et al. [33] |
DUSP28 | Activator of MAPK pathway | Wang et al. [91] |
HYAL1, HYAL2 | Overexpressed in the placenta of the smallest pig fetuses | Vallet et al. [92] |
LTBP1 | TGFB signaling, role in the regulation of human height | Lango Allen et al. [31] |
MAGOH | Influences MAPK | Roignant and Treisman [93] |
MAPK1 | Coding central proteins ERK2 in the Ras/ MAPK | Reviewed by Cobb et al. [94] |
NDUFB9 | Severe growth-hormone deficiency | Riedl et al. [95] |
OSM | Diabetes type II | Sanchez-Infantes et al. [96] |
PATZ1 | Null mice were retarded in growth, Homozygote animals were 10 to 20% smaller, than their litter mates of the same sex | Valentino et al. [34] |
PKP2 | Associates EGF | Kazlauskas [97] |
PPARG | Muscle specific expression; deletion causes insulin resistance in mice; key role in pig growth; reduced size in pre-pubertal children | Crooks et al. [43]; Hevener et al. [42]; Puig-Oliveras et al. [44]; Cecil et al. [45] |
PRKAR2A | Obesity and lipid metabolism | Park et al. 2012 [98] |
PTPRR | Member of the MAPK pathway | Hendriks et al. [99] |
SOD1 | Depressor of the MAPK pathway central genes ERK1/2 | Juarez et al. [100] |