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Table 2 Candidate genes from potentially enriched ontologies with putative functional link to minipigs

From: Analysis of porcine body size variation using re-sequencing data of miniature and large pigs

Gene name

Function

Reference

ACACB

Downregulated by TGFB1; influencing type-II-diabetes; obesity and lipid metabolism

Zhou et al. [87]; Ma et al. [88]

ACOT4

Linked to FGF21 in mice

Muise et al. [89]

ADAMTS12

Blocks Ras/ MAPK pathway

Llamazares et al. [90]

COMT

Reduced birth weight in humans

Sata et al. [33]

DUSP28

Activator of MAPK pathway

Wang et al. [91]

HYAL1, HYAL2

Overexpressed in the placenta of the smallest pig fetuses

Vallet et al. [92]

LTBP1

TGFB signaling, role in the regulation of human height

Lango Allen et al. [31]

MAGOH

Influences MAPK

Roignant and Treisman [93]

MAPK1

Coding central proteins ERK2 in the Ras/ MAPK

Reviewed by Cobb et al. [94]

NDUFB9

Severe growth-hormone deficiency

Riedl et al. [95]

OSM

Diabetes type II

Sanchez-Infantes et al. [96]

PATZ1

Null mice were retarded in growth, Homozygote animals were 10 to 20% smaller, than their litter mates of the same sex

Valentino et al. [34]

PKP2

Associates EGF

Kazlauskas [97]

PPARG

Muscle specific expression; deletion causes insulin resistance in mice; key role in pig growth; reduced size in pre-pubertal children

Crooks et al. [43]; Hevener et al. [42]; Puig-Oliveras et al. [44]; Cecil et al. [45]

PRKAR2A

Obesity and lipid metabolism

Park et al. 2012 [98]

PTPRR

Member of the MAPK pathway

Hendriks et al. [99]

SOD1

Depressor of the MAPK pathway central genes ERK1/2

Juarez et al. [100]