| Patient A# | Patient B | Patient C | Patient D | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Drug | genea | A1# | A2 | A3 | A4 | A5 | B1 | B2 | B3 | C1 | C2 | C3 | C4 | C5 | D1 | D2 | D3 | D4 | D5 |
H | katGa | T326Â M | T326Â M | T326Â M | T326Â M | T326Â M | Y98S | Y98S | Y98S | S315Â T | S315Â T | S315Â T | S315Â T | S315Â T | S315Â T | S315Â T | S315Â T | S315Â T | S315Â T |
inhA promotor | −15, C-T | −15, C-T | − 15,C-T | −15, C-T | − 15,C-T |  |  |  | −15, C-T | −15, C-T | − 15, C-T | −15, C-T | − 15, C-T |  |  |  |  |  | |
R | rpoB | H526L | H526L | H526L | H526L | H526L | H526D | H526D | H526D | D516V | D516V | N373D/ D516V | N373D/ D516V | N373D/ D516V | S531Â L | S531Â L | S531Â L | S531Â L | S531Â L |
Z | pncA | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T | A87T/ L120P | A87T/ L120P | A87T/ L120P | A87T/ L120P |
E | embB | M306Â V | M306Â V | M306Â V | M306Â V | M306Â V | Y319S | Y319S | Y319S | G406A | G406A | G406A | G406A | G406A | M306Â V | M306Â V | M306Â V | M306Â V | M306Â V |
Rv3806c | Â | Â | Â | Â | Â | Â | A249G | A249G | Â | Â | Â | Â | Â | F140Â V | F140Â V | F140Â V | F140Â V | F140Â V | |
Rv3756c (proZ) | G56D | G56D | G56D | G56D | G56D | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
Rv1699 (pyrG) | Â | Â | Â | G407D | G407D | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
S | rpsL | K88R | K88R | K88R | K88R | K88R | Â | Â | Â | Â | Â | Â | Â | Â | Â | K43R | K43R | K43R | K43R |
rrs | Â | Â | Â | Â | Â | c1402t/ a1482g | c1402t/ a1482g | c1402t/ a1482g | a514c c1402t | a514c c1402t | a514c c1402t | a514c c1402t | a514c c1402t | a1401g | a1401g | a1401g | a1401g | a1401g | |
LFX | gyrA | D94G | D94G | D94G | D94G | D94G | A90V | A90V | A90V | A90V | A90V/ S91P | A90V/ S91P | A90V/ S91P | A90V/ S91P | Â | D94N | D94N/ A90V | D94N/ A90V | D94N/ A90V |
PAS | Rv2447c (folC) | Â | I43T | I43T | I43T | I43T | E153G | E153G | E153G | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Amk | Rv2416c (eis) | Â | Â | Â | P2L | P2L | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
MDR+ | Rv1129c | P131T | P131T | P131T | P131T | P131T | P131T | P131T | P131T | D160A | D160A | D160A | D160A | D160A | P131T | P131T | P131T | P131T | P131T |
CPM/Amk | Rv0323c | Â | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L | V215Â L |
LFX/ETH | Rv0404 (fadD30) | Â | Â | Â | Â | Â | Â | L10R | L10R | L10R | L10R | L10R | L10R | L10R | L10R | L10R | L10R | L10R | L10R |
CPM/Amk/ LFX/ETH | Rv0565c | Â | Â | Â | Â | Â | F68I | F68I | F68I | Â | Â | Â | Â | Â | Â | T402Â M | T402Â M | T402Â M | T402Â M |
ETH + Amk | Rv2080 (lppJ) |  |  |  |  |  | S82a | S82a | S82a | S82a | S82a | S82a | S82a | S82a |  |  |  |  |  |
ETH + Amk + CMP + S | Rv2447c (folC) |  | I43T | I43T | I43T | I43T | E153G | E153G | E153G |  |  |  |  |  |  |  |  |  |  |
Drugs ever used | Â | H R Z E | E Pa LFX PAS Amk | E Clr Pa LFX PAS Amk | E Clr Pa LFX PAS Amk | E Clr Pa LFX PAS Amk | R Z CPM LFX ETH Clr | R Z CPM LFX ETH Clr | E Clr PAS MFX Rfb | E Amk PAS ETH LFX | E Amk PAS ETH LFX | E Amk PAS ETH LFX | E Amk PZA PAS ETH LFX | E Amk PZA PAS ETH LFX | E Z Amk Clr CPM LFX | E Z Amk Clr CPM LFX | E Z S Amk Clr CFZ MFX | E Z S Amk Clr CFZ MFX | E Z S Amk Clr CFZ MFX |
Resistant to | Â | H R S LFX ETH | H R S LFX ETH PAS | H R S LFX ETH PAS | H R S LFX Amk ETH PAS | H R S LFX Amk ETH PAS | H R LFX ETH PAS | H R LFX ETH PAS CPM | H R E S LFX ETH PAS CPM | H R CPM | H R Lfx CPM | H R Lfx CPM | H R Lfx CPM | H R S Lfx CPM | H R LFX ETH PAS | H R LFX Amk ETH PAS | H R LFX Amk ETH PAS | H R S LFX Amk ETH PAS | H R S E Amk LFX ETH PAS CPM |