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Table 2 Medication and drug resistance of the phenotypes and genotypes of four refractory tuberculosis patients

From: In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment

  Patient A# Patient B Patient C Patient D
Drug genea A1# A2 A3 A4 A5 B1 B2 B3 C1 C2 C3 C4 C5 D1 D2 D3 D4 D5
H katGa T326 M T326 M T326 M T326 M T326 M Y98S Y98S Y98S S315 T S315 T S315 T S315 T S315 T S315 T S315 T S315 T S315 T S315 T
inhA promotor −15, C-T −15, C-T − 15,C-T −15, C-T − 15,C-T     −15, C-T −15, C-T − 15, C-T −15, C-T − 15, C-T      
R rpoB H526L H526L H526L H526L H526L H526D H526D H526D D516V D516V N373D/ D516V N373D/ D516V N373D/ D516V S531 L S531 L S531 L S531 L S531 L
Z pncA A87T A87T A87T A87T A87T A87T A87T A87T A87T A87T A87T A87T A87T A87T A87T/ L120P A87T/ L120P A87T/ L120P A87T/ L120P
E embB M306 V M306 V M306 V M306 V M306 V Y319S Y319S Y319S G406A G406A G406A G406A G406A M306 V M306 V M306 V M306 V M306 V
Rv3806c        A249G A249G       F140 V F140 V F140 V F140 V F140 V
Rv3756c (proZ) G56D G56D G56D G56D G56D              
Rv1699 (pyrG)     G407D G407D              
S rpsL K88R K88R K88R K88R K88R           K43R K43R K43R K43R
rrs       c1402t/ a1482g c1402t/ a1482g c1402t/ a1482g a514c c1402t a514c
c1402t
a514c
c1402t
a514c
c1402t
a514c
c1402t
a1401g a1401g a1401g a1401g a1401g
LFX gyrA D94G D94G D94G D94G D94G A90V A90V A90V A90V A90V/ S91P A90V/ S91P A90V/ S91P A90V/ S91P   D94N D94N/ A90V D94N/ A90V D94N/ A90V
PAS Rv2447c (folC)   I43T I43T I43T I43T E153G E153G E153G           
Amk Rv2416c (eis)     P2L P2L              
MDR+ Rv1129c P131T P131T P131T P131T P131T P131T P131T P131T D160A D160A D160A D160A D160A P131T P131T P131T P131T P131T
CPM/Amk Rv0323c   V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L V215 L
LFX/ETH Rv0404 (fadD30)        L10R L10R L10R L10R L10R L10R L10R L10R L10R L10R L10R L10R
CPM/Amk/ LFX/ETH Rv0565c       F68I F68I F68I        T402 M T402 M T402 M T402 M
ETH + Amk Rv2080 (lppJ)       S82a S82a S82a S82a S82a S82a S82a S82a      
ETH + Amk + CMP + S Rv2447c (folC)   I43T I43T I43T I43T E153G E153G E153G           
Drugs ever used   H R Z E E Pa LFX PAS Amk E Clr Pa LFX PAS Amk E Clr Pa LFX PAS Amk E Clr Pa LFX PAS Amk R Z CPM LFX ETH Clr R Z CPM LFX ETH Clr E Clr PAS MFX Rfb E Amk PAS ETH LFX E Amk PAS ETH LFX E Amk PAS ETH LFX E Amk PZA PAS ETH LFX E Amk PZA PAS ETH LFX E Z Amk Clr CPM LFX E Z Amk Clr CPM LFX E Z S Amk Clr CFZ MFX E Z S Amk Clr CFZ MFX E Z S Amk Clr CFZ MFX
Resistant to   H R S LFX ETH H R S LFX ETH PAS H R S LFX ETH PAS H R S LFX Amk ETH PAS H R S LFX Amk ETH PAS H R LFX ETH PAS H R LFX ETH PAS CPM H R E S LFX ETH PAS CPM H R CPM H R Lfx CPM H R Lfx CPM H R Lfx CPM H R S Lfx CPM H R LFX ETH PAS H R LFX Amk ETH PAS H R LFX Amk ETH PAS H R S LFX Amk ETH PAS H R S E Amk LFX ETH PAS CPM
  1. H isoniazid, R rifampin, S streptomycin, Z pyrazinamide, E ethambutol, LFX levofloxacin, MFX moxifloxacin, PAS p-aminosalicylic acid sodium, Amk amikacin, ETH ethionamide, CPM capreomycin, Clr clarithromycin, CFZ Clofazimine
  2. adrug-resistant related genes mainly based on the report by Zhang et al. [5]
  3. #A, B, C, and D indicate the four cases, and the number following them indicates the different isolates