Fig. 2

Overview of literature curation scheme. We sought papers which study the functional distinctness of a single human or mouse gene’s splice isoforms. Positive studies are those that provide evidence where multiple splice isoforms of a single gene are depleted and at least two isoforms show a phenotype. We annotated studies as providing negative evidence for functional distinctness when investigators deplete multiple splice isoforms of the same gene but only one produces an observable phenotype. The numbers in bold represent the number of studies in each category. Clip art designed from Flaticon (free license with attribution)