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Table 4 Most genes with FDSIs have biochemically distinct splice isoforms

From: Systematic evaluation of isoform function in literature reports of alternative splicing

  Types of distinctness Human genes Mouse genes
Distinct expression patterns Cell-type-specific AR, MADD  
Developmental-stage-specific CD44 Myh10, Robo3
Cellular localization BIRC5, CSPP1, PRMT5, PML Myh10, Rbfox1, Robo3, Sirt3
Tissue-specific MST1R Calca, Rock2
Other-condition-specific BOK  
Biochemically distinct Protein domain CFLAR, DPF3, EIF4G1, TICAM1, TP63 Lrp8
Dominant negative BIRC5, HBS1L, KLF6, Nf1, PRMT5, STIM2, SUN1, TICAM Enc1, Nf1, Robo3, Ryr3, Tp63
Protein terminus change BCAR1, BDNF, EIF4G2, IL1RAP, PGAM5 Cacna1b, Mecp2, Oprm1, Pn4
UTR Change BDNF  
  1. Genes with FDSIs were categorized on functional type based on the literature that reported on the FDSIs using the scheme outlined in Fig. 1. Genes categorized as “distinct expression patterns” express FDSIs in specific conditions. Genes categorized as “biochemically distinct” have FDSIs whose functional distinctness is a consequence of biochemical differences in their final protein product. Genes can be categorized as both “distinct expression patterns” and “biochemically distinct” such as Myh10 and Robo3