Fig. 6

Network analysis of lncRNAs and their associations with known protein-coding genes in the mouse in vivo embryo and NT embryos during pre-implantation development and cell reprogramming. a, Hierarchical cluster tree showing co-expression modules identified using WGCNA. The modules correspond to branches and are labelled by colours, as indicated by the colour band underneath the tree. b, Heatmap showing correlations followed by the P-values (p < 0.05) in parentheses between modules, development, reprogramming and donor cell type. The colour of each square corresponds to the degree of correlation: positive correlation, red; negative correlation, green; no correlation, white. c, Co-expressed lncRNAs and protein-coding genes in the largest module that are closely related to mouse embryonic development. d, Correlation plot of 20 module genes with development, reprogramming and donor cell type. Each row and column in the heatmap corresponds to 1 module gene (labeled by the same colour as that in a). In the heatmap, the red colour represents high adjacency (positive correlation), and the blue colour represents low adjacency (negative correlation)