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Table 2 Predicted activation or inhibition of IPA canonical pathways in Fayoumi bursa

From: Immunomodulatory effects of heat stress and lipopolysaccharide on the bursal transcriptome in two distinct chicken lines

Canonical Pathwaysa

Nb

Top Associated Genesc

z-score

Heat + Saline

   

 ---

---

---

---

Thermoneutral + LPS

   

 GP6 Signaling Pathway

11

COL2A1, LAMA2, CAMK4, COL6A3, COL4A6

3.32

 Integrin Signaling

11

MYL9, ACTG2, ACTA2, MYLK, RND3

3.00

 Cardiac Hypertrophy Signaling

10

CACNA1E, HSPB1, MYL9, PLCL1, CAMK4

3.00

 Calcium Signaling

11

CACNA1E, CHRNA3, CHRNA7, TPM2, MYL9

2.65

 Signaling by Rho Family GTPases

15

FOS, MYL9, ACTG2, DES, ACTA2

2.50

 Thrombin Signaling

10

MYL9, PLCL1, MYLK, CAMK4, RND3

2.45

 Dopamine-DARPP32 Feedback in cAMP Signaling

8

CACNA1E, PLCL1, KCNJ8, PRKG1, DRD1

2.45

 ILK Signaling

10

FOS, MYL9, ACTG2, ACTA2, RND3

2.33

 Leukocyte Extravasation Signaling

8

MMP1, ACTG2, CTNNA2, ACTA2, JAM3

2.24

 CXCR4 Signaling

7

FOS, MYL9, EGR1, RND3, RHOB

2.24

 PI3K Signaling in B Lymphocytes

6

FOS, ATF3, PLCL1, CAMK4, JUN

2.24

 Cholecystokinin/Gastrin-mediated Signaling

5

FOS, RND3, RHOB, JUN, CREM

2.24

 Tec Kinase Signaling

6

FOS, ACTG2, ACTA2, RND3, RHOB

2.24

 Intrinsic Prothrombin Activation Pathway

4

COL2A1, COL1A2, COL1A1, COL3A1

2.00

 Agrin Interactions at Neuromuscular Junction

5

LAMA2, ACTG2, ACTA2, AGRN, JUN

2.00

Heat + LPS

   

 Superpathway of Cholesterol Biosynthesis

4

PMVK, MVD, EBP, FDPS

-2.00

 Osteoarthritis Pathway

15

BGLAP, GLI1, IL1B, HES1, SP1

-2.11

 Role of Wnt/GSK-3β Signaling in Pathogenesis of Influenza

6

WNT6, WNT10A, WNT11, FZD2, WNT5B

-2.24

 Wnt/Ca+ pathway

6

FZD2, WNT5B, PLCD4, PLCD3, RELA

-2.45

 PCP pathway

8

WNT6, WNT10A, WNT11, EFNB1, JUND

-2.82

 Colorectal Cancer Metastasis Signaling

12

WNT6, WNT10A, WNT11, PTGER2, IL6R

-2.89

 Glioblastoma Multiforme Signaling

9

WNT6, WNT10A, WNT11, EGF, FZD2

-3.00

  1. aPathways shown for each treatment have significant associations (−log(p-value) > 1.3) and predicted activation (z-score ≥ 2) or inhibition (z-score ≤ − 2)
  2. bTotal number of significant DE genes associated with each pathway (N)
  3. cFor each pathway, the five significant genes (q-value < 0.05) with the largest |log2FC| are shown
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BMC Genomics

ISSN: 1471-2164

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