Immunomodulatory effects of heat stress and lipopolysaccharide on the bursal transcriptome in two distinct chicken lines

Table 4 Predicted functional effects of treatment were different in broiler and Fayoumi lines

Treatment^a	Fayoumi > Broiler	Broiler > Fayoumi
Heat + Saline	• cell movement	• movement disorders • mass of organism • colitis • abnormality of large intestine • skin lesion
Thermoneutral + LPS	• size of body • organization of cytoskeleton • organization of cytoplasm • microtubule dynamics • cell movement	• organismal death • morbidity and mortality • perinatal death • neonatal death • bleeding
Heat + LPS	• neoplasia of leukocytes • neurodegeneration	• cell movement • invasion of carcinoma cell lines • cell movement of carcinoma cell lines • migration of carcinoma cell lines

^aDown-stream effects of each treatment were predicted using IPA (−log(p-value) > 1.3, |z-scores| ≥ 2). Top five functions (greatest |z-scores|) are shown for each line comparison. Analyses excluded basal line differences (848 genes significant in the comparison between lines for Thermoneutral + Saline; Additional files 3 and 7)

ISSN: 1471-2164