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Table 1 Genetic variants associated with human bitter taste perception

From: Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste

Trait 1 SNP Chr:Position A1/A2 MAF β SE r2 P Trait 2
Quinine Caffeine SOA DB
Quinine rs10772420 12:11174276 G/A 0.469 -0.337 0.034 5.67% 7.8e-23* - 4.8e-65* 1.8e-24* 6.4e-26*
Caffeine rs2597979 12:11189966 G/C 0.163 0.264 0.048 1.91% 4.2e-8 8.4e-24* - 2.8e-10* 4.5e-11*
SOA rs67487380 12:11194384 A/G 0.275 -0.202 0.040 1.63% 3.8e-7 5.4e-13* 4.5e-8 - 2.4e-6
DB rs10261515 7:141398707 G/A 0.491 -0.136 0.037 0.93% 2.5e-4 3.1e-8 4.0e-6 5.6e-4 -
PROP solution rs10246939 7:141672604 C/T 0.443 0.968 0.028 46.20% 2.8e-199*     
PROP paper rs10246939 7:141672604 C/T 0.441 0.534 0.032 14.08%a 5.4e-59*     
PROP paper rs6761655 2:218218646 G/A 0.186 -0.246 0.044 1.83% 2.7e-8     
  1. We report the top SNP from the peak association. SNPs that were not identified in our previous GWAS are shown in italics. Allele frequency and effect sizes are reported with reference to allele A1. Base-pair position is based on GRCh37; A1/A2, minor/major allele; MAF, minor allele frequency; β, the effect size; SE, standard error of the β; r2, percent variance of the trait accounted for by the SNP; P, P-value from the univariate association analysis of trait 1; P_bivariate, P-value from the bivariate association analysis of traits 1 and 2; SOA, sucrose octaacetate; DB, denatonium benzoate; bold, P < genome-wide significance threshold of 5.0e-8; *, P < corrected significance threshold of 1.0e-8; , an independent replication; , no evidence of replication. See Additional files for the full list of SNPs (Additional file 1: Table S1, Additional file 2: Table S2, Additional file 3: Table S3, Additional file 4: Table S4, Additional file 5: Table S5, Additional file 6: Table S6, Additional file 7: Table S7)
  2. ars10246939 accounted only a third of the variance in PROP paper compared to PROP solution. This was partly due to the lower heritability of PROP paper (h2 = 0.40) compared to PROP solution (h2 = 0.71, Additional file 8: Table S8)