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Table 2 Conditional analyses of correlated SNPs on chromosome 12 associated with the perception of quinine, caffeine and sucrose octaacetate (SOA)

From: Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste

Trait SNP Chr:Position Association (P-value) Association conditional on correlated SNP (P-value)
rs10772420 rs2597979 rs67487380
Quinine rs10772420 12:11174276 7.8e-23 - 3.0e-19 1.5e-10
rs2597979 12:11189966 4.3e-3 4.4e-2 - -
rs67487380 12:11194384 1.5e-13 0.12 - -
Caffeine rs10772420 12:11174276 2.5e-3 - 0.38 -
rs2597979 12:11189966 4.2e-8 4.4e-6 - 9.7e-8
rs67487380 12:11194384 0.11 - 0.47 -
SOA rs10772420 12:11174276 1.0e-4 - - 0.47
rs2597979 12:11189966 0.38 - - 0.63
rs67487380 12:11194384 3.8e-7 7.6e-4 5.3e-7 -
  1. r2 = 0.24 between rs10772420 and rs2597979; r2 = 0.43 between rs10772420 and rs67487380; r2 = 0.08 between rs2597979 and rs67487380. SNP in bold in the second column are index SNPs for the corresponding traits from Table 1. Base-pair position is based on GRCh37