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Fig. 5 | BMC Genomics

Fig. 5

From: Systematic evaluation of signal-to-noise ratio in variant detection from single cell genome multiple displacement amplification and exome sequencing

Fig. 5

Coefficient of variation or signal-to-noise (SNR) ratio as an unbiased measure of heterozygous allelic dispersion and quality. As allele dropout is ambiguously defined, we suggest the addition of SNR of heterozygous variants to describe the quality of single or sparse cell data. It is defined as the level of true signal, here represented as heterozygous alleles of one-half, compared to the level of the background noise or dispersion as defined as the standard deviation of the allele frequencies, i.e. the reciprocal of the coefficient of variation

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