Table 2 IPA summary of the liver transcriptome in the E16 vs. E20 contrast
Top Canonical Pathways | p-value | Overlap | Ratio |
LPS/IL-1 Mediated Inhibition of RXR Function | 4.21E-06 | 17.9% | 24/134 |
Mitotic Roles of Polo-Like Kinase | 8.94E-06 | 26.5% | 13/49 |
Complement System | 9.91E-06 | 37.5% | 9/24 |
Tyrosine Degradation I | 8.12E-05 | 80.0% | 4/5 |
Cell Cycle Control of Chromosomal Replication | 1.23E-04 | 23.9% | 11/46 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
E2F4 | 2.52E-23 | 52 | |
TCF3 | 1.14E-19 | 56 | |
PPARA | 1.54E-15 | 57 | |
E2F1 | 1.98E-15 | 62 | |
TCF4 | 6.52E-14 | 36 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Cell Cycle | 1.35E-03 - 7.51E-18 | 212 | |
Cellular Assembly and Organization | 1.02E-03 - 7.51E-18 | 118 | |
DNA Replication, Recombination, and Repair | 1.02E-03 - 7.51E-18 | 150 | |
Cell Death and Survival | 1.33E-03 - 1.54E-11 | 350 | |
Cell Morphology | 2.22E-04 - 1.71E-11 | 74 | |
Physiological System Development and Function | p-value | # Genes | |
Reproductive System Development and Function | 5.11E-04 - 2.03E-06 | 23 | |
Digestive System Development and Function | 4.37E-04 - 7.57E-05 | 18 | |
Organ Morphology | 4.37E-04 - 7.57E-05 | 21 | |
Organismal Development | 4.37E-04 - 7.57E-05 | 142 | |
Behavior | 1.52E-04 - 1.52E-04 | 18 | |
Top Toxicity Functions | p-value | # Genes | Ratio |
LPS/IL-1 Mediated Inhibition of RXR Function | 1.70E-05 | 16.6% | 24/145 |
Fatty Acid Metabolism | 6.31E-05 | 21.2% | 14/66 |
Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 2.09E-04 | 24.4% | 10/41 |
Genes Upregulated in Response to Chronic Renal Failure | 1.02E-03 | 75.0% | 3/4 |
Transmembrane Potential of Mitochondria and Membrane | 1.50E-03 | 16.5% | 13/79 |
Top Up-regulated Genes | log2 Ratio | Top Down-regulated Genes | log2 Ratio |
DIO3 | 3.65 | DIO2 | −7.19 |
ACMSD | 3.65 | SERPINA3 | −5.55 |
ANGPTL3 | 3.62 | HPX | −4.61 |
HDAC9 | 3.35 | FKBP5 | −4.37 |
GAS2 | 3.19 | CA4 | −4.20 |
CHODL | 3.11 | FABP1 | −4.07 |
CKS2 | 3.02 | KLF9 | −3.64 |
CKAP2 | 2.97 | IP6K2 | − 3.61 |
AURKA | 2.93 | SLCO1A2 | −3.60 |
KPNA2 | 2.90 | ITIH3 | −3.49 |