Table 4 IPA summary of the liver transcriptome in the E18 vs. D1 contrast
Top Canonical Pathways | p-value | Overlap | Ratio |
Cell Cycle Control of Chromosomal Replication | 9.58E-07 | 41.3% | 19/46 |
Mitotic Roles of Polo-Like Kinase | 5.36E-05 | 34.7% | 17/49 |
NRF2-mediated Oxidative Stress Response | 5.68E-05 | 24.3% | 36/148 |
Role of BRCA1 in DNA Damage Response | 6.89E-05 | 30.4% | 21/69 |
Hereditary Breast Cancer Signaling | 2.05E-04 | 24.8% | 29/117 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
TP53 | 3.51E-20 | 228 | |
E2F4 | 1.61E-17 | 63 | |
E2F1 | 5.07E-17 | 96 | |
ESR1 | 2.04E-14 | 193 | |
TCF3 | 1.50E-12 | 67 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Cell Cycle | 1.11E-03 - 8.65E-14 | 366 | |
Cellular Assembly and Organization | 1.11E-03 - 8.65E-14 | 276 | |
DNA Replication, Recombination, and Repair | 1.11E-03 - 8.65E-14 | 265 | |
Cell Death and Survival | 1.07E-03 - 4.85E-13 | 626 | |
Lipid Metabolism | 1.11E-03 - 1.49E-07 | 252 | |
Physiological System Development and Function | p-value | # Genes | |
Embryonic Development | 1.11E-03 - 1.20E-05 | 140 | |
Organismal Survival | 1.20E-05 - 1.20E-05 | 36 | |
Reproductive System Development and Function | 5.21E-04 - 1.87E-05 | 27 | |
Hematological System Development and Function | 1.09E-03 - 5.24E-05 | 27 | |
Hematopoiesis | 1.09E-03 - 5.24E-05 | 21 | |
Top Toxicity Functions | p-value | Overlap | Ratio |
NRF2-mediated Oxidative Stress Response | 7.48E-06 | 25.2% | 41/163 |
Liver Necrosis/Cell Death | 2.94E-04 | 20.9% | 46/220 |
Liver Proliferation | 7.86E-04 | 21.1% | 38/180 |
FXR/RXR Activation | 1.43E-03 | 24.3% | 20/79 |
LXR/RXR Activation | 3.31E-03 | 24.7% | 18/73 |
Top Up-regulated Genes | log2 Ratio | Top Down-regulated Genes | log2 Ratio |
DIO3 | 4.82 | SLCO1A2 | −6.69 |
SLC13A3 | 4.67 | DIO2 | −5.44 |
MOGAT1 | 4.44 | ELOVL5 | −4.96 |
RET | 4.37 | COCH | −4.96 |
TTLL2 | 4.25 | FABP1 | −4.63 |
ASCL1 | 3.94 | HIGD1A | −4.63 |
PPM1K | 3.93 | HPS5 | −4.63 |
ALKAL2 | 3.76 | SLC51A | −4.60 |
TFPI | 3.47 | CYP7A1 | −4.54 |
ATP2B2 | 3.35 | HMGCS1 | −4.46 |