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Table 6 Temperature stress response discovery analysis. Discovery analysis utilized the MGL 2007-2009 Temperature data set (cGRASP44K) from Jeffries et al. [9], and publicly available data from the Quinn et al. [32] study on chronic, sub-lethal heat stress in Arctic charr gill tissue (cGRASP32K). Validation analyses were based on robustness signatures CS0101i and CS0101u, and published signatures ES0013 (cGRASP44K), ES0012, ES0020, ES0021, ES0022 (GRASP16K), and ES0023 and ES0024 (cGRASP32K)

From: Developing specific molecular biomarkers for thermal stress in salmonids

Signature Data set Species Exposure duration Tissue Array platform Signature
ES0012 Jeffries et al. [30], Chronic heat (survivors) Sockeye salmon Chronic Gill cGRASP16K Publication Table S1A [30]
ES0013 Jeffries et al. [9], Chronic heat Pink and Sockeye salmon Chronic Gill cGRASP44K Publication Table S4 [9]
ES0024 Quinn et al. [32], Chronic heat Arctic charr Chronic Gill cGRASP32K Publication Table S1 [32]
ES0023 Quinn et al. [33], Heat tolerance Arctic charr Acute Gill cGRASP32K Publication Table S2 [33] (union A-G; 444 features)
ES0020 Lewis et al. [34], 24 h post-treatment Rainbow trout Acute Red blood cells cGRASP16K Publication Table 4 [34]
ES0021 Lewis et al. [34], 4 h post-treatment Rainbow trout Acute Red blood cells cGRASP16K Publication Table 2 [34]
ES0022 Anttila et al. [12], Cardiac response to warming Sockeye salmon Chronic Cardiac cGRASP16K Publication Table SI [12]
DS0101 2007 Robust limma signature (FDR < 0.01) Sockeye salmon Chronic Gill cGRASP44K Derived in discovery analysis
DS0102 2008 Robust limma signature (FDR < 0.01) Sockeye salmon Chronic Gill cGRASP44K Derived in discovery analysis
DS0103 2009 Robust limma signature (FDR < 0.01) Pink salmon Chronic Gill cGRASP44K Derived in discovery analysis
CS0101i Temperature 2007–2009 Discovery (FDR < 0.01; Intersection) Pink and Sockeye salmon Chronic Gill cGRASP44K Derived in discovery analysis
CS0101u Temperature 2007–2009 Discovery (FDR < 0.01; Union) Pink and Sockeye salmon Chronic Gill cGRASP44K Derived in discovery analysis
EX0101a 2009 Temperature Gene Shaving Cluster 5 (“Shave5”) Pink salmon Chronic Gill cGRASP44K Derived in discovery analysis
EX0102a 2007 Temperature Gene Shaving Cluster 4 (“Shave4”) Sockeye salmon Chronic Gill cGRASP16K Derived in discovery analysis
EX0103a 2008 Temperature Combined sPCA2 + sPCA3 Sockeye salmon Chronic Gill cGRASP44K Derived in discovery analysis
DS0104 Robust limma signature (FDR < 0.01), Heat tolerance data Arctic Charr Acute Gill cGRASP32K Derived in discovery analysis