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Fig. 1 | BMC Genomics

Fig. 1

From: Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure

Fig. 1

Divergent transcriptional profiles SR-B1 KO and wild-type embryos. a. Differentially expressed genes in each group of embryos are shown in a Venn diagram. b. Single genes with differential expression of over 2-fold were used to cluster samples hierarchically. The heatmap shows the fold change of the relative expression levels of each gene relative to the grand mean. c. Principal component analysis of each sample using all the differentially expressed genes. Percentage of the total variance explained by each principal component (PC) is shown in brackets. d. Gene set enrichment analysis of genes underexpressed in KO-NTD embryos compared to both WT and KO-N embryos. Processes related to neural development are shown in orange boxes. e. Enrichment analysis of genes overexpressed in KO-NTD embryos compared to WT and KO-N embryos. Processes involved in lipid metabolism are highlighted in orange boxes

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BMC Genomics

ISSN: 1471-2164

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