Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus)

Table 5 The SNPs in the bovine SIRT6 that alter or are adjacent to the cis-acting elements

Locus	Genotype	Transcription factors	Cis-acting elements (Recognition sequence^a)	Target strand
c.-84 C > T	C	Nuclear respiratory factor 1	cacggCGCAtgcgcctt	(+)
	C	C2H2 zinc finger transcription factors 15	cacggcgcaTGCGcctt	(+)
	C	Mouse Krueppel like factor	cacggcgcatgcgCCTTgcga	(+)
	T	Nuclear respiratory factor 1	cacggCGCAtgcgcctt	(+)
	T	C2H2 zinc finger transcription factors 15	cacggcgcaTGCGcctt	(+)
	T	Mouse Krueppel like factor	cacggcgcatgcgCCTTgcga	(+)
c.-1100 A > G	A	NKX homeodomain factors	agggtTGAGtgctgggagc	(−)
	A	Brachyury gene, mesoderm developmental factor	gagctgatcaGGTGtcagggttgagtgct	(−)
	A	Calsenilin, presenilin binding protein, EF hand transcription factor	gtGTCAgggtt	(−)
	G	Selenocysteine tRNA activating factor	tgcacccgcagcTCCCagcactcaaccc	(+)
	G	NKX homeodomain factors	agggtTGAGtgctgggagc	(−)
	G	Brachyury gene, mesoderm developmental factor	gagctgatcaGGTGtcagggttgagtgct	(−)
	G	Calsenilin, presenilin binding protein, EF hand transcription factor	gtGTCAgggtt	(−)

^aSNP loci in tables, capital letters are core sequence of the transcription factors, and the letters with ci value > 85 are underlined

ISSN: 1471-2164