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Table 2 Prevalence of mutations in different clades of the Ural genotype

From: New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe

Gene, codon or position

Clade A (n = 31)

Clade B (n = 52)

Clade C sensu stricto (n = 33)

Clade Ca (n = 39)

Other (n = 27)

rpoB

 Ser450Leu

2

12

31

34

15

 445

1

1

  

1

 452

 

1

   

 435

  

1

1

 

 Ser450Trp

  

1

1

 

rpoC Asp485Asn

 

7

  

4

katG Ser315Thr

5

33

33

38

20

fibG1 (inhA) -15 C > T

 

7

33

34

5

ahpC promoter

1

1

   

rpsL

 43

 

6

 

1

1

 88

2

10

33

35

11

embB

 297

  

29

29

2

 306

1

6

1

2

7

 319

 

2

   

 406

 

2

1

3

1

 497

 

3

2

2

3

 1002

 

1

   

 1024

   

2

 

embA

 -12 C > T

1

    

 -16 C > T

  

8

8

 

rrs

 517

 

1

   

 1401

    

2

eis

 -12G > A

1

3

33

33

3

 -15G > C

 

2

  

1

 -37C > A

 

1

   

 -10C > T

    

1

gyrA

 90

  

1

1

2

 94

 

1

1

1

4

pncA

 13

  

1

1

 

 160

  

1

1

 

 -7

  

1

1

 

 12

  

4

4

 

 14

  

2

2

 

 -11

  

1

1

2

 34

  

1

1

 

 128

 

1

  

1

 10

   

2

 

 159

    

1

  1. aClade C includes “Clade C strict sense” plus pre-Clade C isolates (refer to different rose shade on dendrogram in Additional file 5). In few strains, two embB mutations were found