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Table 2 Prevalence of mutations in different clades of the Ural genotype

From: New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe

Gene, codon or position Clade A (n = 31) Clade B (n = 52) Clade C sensu stricto (n = 33) Clade Ca (n = 39) Other (n = 27)
rpoB
 Ser450Leu 2 12 31 34 15
 445 1 1    1
 452   1    
 435    1 1  
 Ser450Trp    1 1  
rpoC Asp485Asn   7    4
katG Ser315Thr 5 33 33 38 20
fibG1 (inhA) -15 C > T   7 33 34 5
ahpC promoter 1 1    
rpsL
 43   6   1 1
 88 2 10 33 35 11
embB
 297    29 29 2
 306 1 6 1 2 7
 319   2    
 406   2 1 3 1
 497   3 2 2 3
 1002   1    
 1024     2  
embA
 -12 C > T 1     
 -16 C > T    8 8  
rrs
 517   1    
 1401      2
eis
 -12G > A 1 3 33 33 3
 -15G > C   2    1
 -37C > A   1    
 -10C > T      1
gyrA
 90    1 1 2
 94   1 1 1 4
pncA
 13    1 1  
 160    1 1  
 -7    1 1  
 12    4 4  
 14    2 2  
 -11    1 1 2
 34    1 1  
 128   1    1
 10     2  
 159      1
  1. aClade C includes “Clade C strict sense” plus pre-Clade C isolates (refer to different rose shade on dendrogram in Additional file 5). In few strains, two embB mutations were found