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Fig. 5 | BMC Genomics

Fig. 5

From: Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin

Fig. 5

Age-related changes in transcript abundance coincide with changes in heterochromatin. a Genes that display age-related changes in expression between 4 M and 20 M at ZT4 (FDR ≤0.02). The genes are further subdivided into 50 annotated (blue scale) and 136 unannotated genes (Grayscale). b Same as in (a) except these loci have age-related changes at ZT16. At ZT16 there were 178 annotated genes (top) and 296 novel genes (bottom) that changed between 4 M and 20 M. Genes represented in the heatmaps are contained in Additional file 5: Tables S2a and b. c Scatter plots showing age-related changes in H3K9me3 between 4 M and 20 M at ZT4 and ZT16 for all loci described in (a) and (b). Loci with significant diurnal changes in H3K9me3 are shown in red. The data are further subdivided into protein-coding genes and lncRNAs. Representative examples of age-related changes in expression and H3K9me3 at genes with OT are visualized with IGV. d At ZT4, slc4a4 has an age-related increase in expression and an age-related decrease in H3K9me3. e At ZT16 there is an age-related loss in fbxo32 and a corresponding increase in H3K9me3

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