Table 2 Amino Acid Uptake, Biosynthesis, and Metabolism in Gastric versus EHS Genomes^a

Serine Family

Transporter

Serine

1/1

11/12

7/11

2/2

3/3

10/11

4/5

3/6

4/4

8/8

13/13

Alanine, Glycine

1/1

5/12

0/11

0/2

1/3

7/11

4/5

2/6

4/4

8/8

13/13

Cysteine

1/1

12/12

11/11

2/2

3/3

11/11

4/5

6/6

0/4

6/8

12/13

Biosynthesis/

Metabolism

Serine → Pyruvate (sdaA)

1/1

9/12

10/11

2/2

3/3

5/11

5/5

6/6

4/4

8/8

13/13

Pyruvate → Alanine

0/1

0/12

11/11

2/2

1/3

0/11

0/5

0/6

0/4

7/8

11/13

Glycerate-3P → Serine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

0/4

7/8

13/13

Serine → Glycine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

4/4

8/8

13/13

Serine → Cysteine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

0/4

5/8

12/13

Aromatic Family

Transporter

Tryptophan

0/1

10/12

0/11

0/2

0/3

0/11

0/5

0/6

0/4

0/8

0/13

Histidine

1/1

12/12

11/11

0/2

1/3

3/11

0/5

3/6

4/4

8/8

13/13

Biosynthesis/

Metabolism

Tryptophan

1/1

10/12

8/11

2/2

3/3

0/11

5/5

6/6

0/4

8/8

12/13

Phenylalanine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

1/4

8/8

1/13

Tyrosine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

0/4

7/8

5/13

Histidine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

0/4

8/8

0/13

Aspartate Family

Transporter

Asparagine/Aspartate

1/1

12/12

11/11

2/2

3/3

11/11

4/5

6/6

0/4

6/8

12/13

Threonine

1/1

0/12

0/11

0/2

0/3

0/11

0/5

0/6

0/4

0/8

0/13

Leucine, Isoleucine, Valine

1/1

12/12

0/11

0/2

0/3

0/11

0/5

0/6

0/4

0/8

0/13

Methionine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

2/4

8/8

5/13

Lysine

0/1

0/12

0/11

2/2

0/3

0/11

0/5

0/6

0/4

5/8

0/13

Biosynthesis/

Metabolism

Asparagine → Aspartate (ansB)

1/1

12/12

11/11

2/2

2/3

11/11

5/5

6/6

4/4

8/8

13/13

Glutamate → Aspartate (aspB)

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

4/4

8/8

13/13

Aspartate → Threonine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

4/4

8/8

13/13

Pyruvate + Threonine → Valine, Leucine, Isoleucine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

0/4

7/8

0/13

Methionine

1/1

12/12

9/11

2/2

3/3

11/11

5/5

6/6

0/4

5/8

0/13

Aspartate → Lysine

1/1

12/12

11/11

2/2

3/3

11/11

5/5

6/6

4/4

8/8

13/13

Glutamate Family

Transporter

Proline

1/1

8/12

11/11

2/2

2/3

3/11

5/5

6/6

3/4

8/8

13/13

Glutamine

1/1

12/12

11/11

2/2

3/3

11/11

4/5

6/6

0/4

6/8

12/13

Glutamate

1/1

12/12

11/11

2/2

3/3

11/11

4/5

6/6

3/4

8/8

13/13

Arginine

0/1

0/12

2/11

0/2

0/3

0/11

0/5

0/6

0/4

4/8

11/13

GABA

0/1

0/12

10/11

0/2

0/3

0/11

0/5

0/6

0/4

0/8

2/13

Urea

0/1

1/12

10/11

0/2

0/3

4/11

0/5

0/6

0/4

8/8

13/13

Biosynthesis/

Metabolism

Proline ↔ Glutamate (putA)

1/1

4/12

11/11

2/2

1/3

2/11

0/5

3/6

2/4

7/8

13/13

Glutamine → Glutamate (ggt)

0/1

1/12

11/11

2/2

1/3

0/11

0/5

1/6

0/4

7/8

13/13

Glutamate → Arginine

0/1

11/12

3/11

2/2

3/3

11/11

5/5

6/6

4/4

6/8

0/13

Glutamate → GABA → Succinate

0/1

0/12

0/11

0/2

0/3

0/11

0/5

0/6

0/4

0/8

6/13

Arginine → Urea

0/1

5/12

9/11

0/2

1/3

8/11

2/5

4/6

0/4

6/8

11/13

Urea → CO₂ + 2 NH₃(urease)

0/1

1/12

10/11

0/2

0/3

4/11

0/5

0/6

0/4

8/8

13/13