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Fig. 5 | BMC Genomics

Fig. 5

From: Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification

Fig. 5

IPA Path Explorer identified a highly interconnected feather-scale co-expression network regulated by β-catenin and all-trans retinoic acid (RA, tretinoin) hubs. Red nodes are genes or chemicals involved in the formation of feathered feet (ptilopody) supported by the literature. White nodes are SFT and FST genes co-expression between feather and scale phenotypes based on recombination experiments. Every line represents a literature-supported relationship between a red and a white node. Solid and dashed lines indicate direct and indirect interactions, respectively. It shows that β-catenin and all-trans retinoic acid (RA, tretinoin) are two key hubs, because most of SFT and FST genes could be regulated by them

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