Fig. 6

ATAC-Seq analysis reveals exemplary active and inhibited chromatin regions after β-catenin and RA perturbation. a. 3,844 significantly enriched ATAC-Seq peaks between RCAS-β-catenin and control. Magenta points are significantly differentially enriched peaks, and blue points are non-differentially enriched peaks. b. Example of ectopic β-catenin induced open chromatin region. c. 2,100 significantly enriched ATAC-Seq peaks after RA treatment. Magenta points are significantly differentially enriched peaks, and blue points are non-differentially enriched peaks. d. Example of RA induced open chromatin region. e. 1,086 differentially enriched peaks overlapped between β-catenin and RA treated samples. f. ATAC-Seq profiles of BMPR1B gene. Regulatory elements near BMPR1B are inhibited by RCAS-Ctnnb1 and retinoic acid (RA), compared to RCAS-GFP. The first and second tracks are RCAS-Ctnnb1, the third and fourth tracks are retinoic acid (RA), and the fifth and sixth tracks are RCAS-GFP