From: Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling
FACTORS considered | Estimated coefficients | std. error | t value | p.value | Factor effect |
---|---|---|---|---|---|
(A) RMA | |||||
Intercept | 6.925 | 0.014 | 512.610 | <2e-16 | – |
(GSE14333+) GSE17536 | 0.387 | 0.019 | 20.230 | <2e-16 | yes |
GSE31595 | −1.212 | 0.019 | −63.440 | <2e-16 | yes |
GSE33113 | −0.577 | 0.019 | −30.210 | <2e-16 | yes |
GSE38832 | −0.355 | 0.019 | −18.570 | <2e-16 | yes |
GSE39084 | −0.978 | 0.019 | −51.180 | <2e-16 | yes |
GSE39582 | −1.375 | 0.019 | −71.970 | <2e-16 | yes |
(B) RMA plus Combat | |||||
Intercept | 6.219 | 0.013 | 473.582 | <2e-16 | – |
(GSE14333+) GSE17536 | 0.000 | 0.019 | 0.001 | 0.999 | no |
GSE31595 | 0.002 | 0.019 | 0.122 | 0.903 | no |
GSE33113 | 0.001 | 0.019 | 0.051 | 0.959 | no |
GSE38832 | −0.001 | 0.019 | −0.033 | 0.973 | no |
GSE39084 | 0.002 | 0.019 | 0.092 | 0.927 | no |
GSE39582 | 0.001 | 0.019 | 0.029 | 0.977 | no |
(C) fRMA | |||||
Intercept | 6.535 | 0.015 | 450.434 | <2e-16 | – |
(GSE14333+) GSE17536 | −0.011 | 0.021 | −0.553 | 0.580 | no so much |
GSE31595 | 0.089 | 0.021 | 4.329 | 0.000 | yes |
GSE33113 | 0.071 | 0.021 | 3.455 | 0.001 | yes |
GSE38832 | 0.054 | 0.021 | 2.641 | 0.008 | yes |
GSE39084 | 0.096 | 0.021 | 4.695 | 0.000 | yes |
GSE39582 | 0.089 | 0.021 | 4.336 | 0.000 | yes |
(D) fRMA plus Combat | |||||
Intercept | 6.590 | 0.014 | 457.338 | <2e-16 | – |
(GSE14333+) GSE17536 | 0.000 | 0.020 | 0.001 | 1.000 | no |
GSE31595 | 0.002 | 0.020 | 0.093 | 0.926 | no |
GSE33113 | 0.001 | 0.020 | 0.072 | 0.942 | no |
GSE38832 | 0.000 | 0.020 | 0.019 | 0.985 | no |
GSE39084 | 0.002 | 0.020 | 0.089 | 0.929 | no |
GSE39582 | 0.000 | 0.020 | 0.007 | 0.994 | no |
(E) fRMA plus mean centered | |||||
Intercept | 0.000 | 0.000 | −1.638 | 0.101 | – |
(GSE14333+) GSE17536 | 0.000 | 0.000 | 1.264 | 0.206 | yes |
GSE31595 | 0.000 | 0.000 | 0.288 | 0.773 | no so much |
GSE33113 | 0.000 | 0.000 | 1.605 | 0.108 | yes |
GSE38832 | 0.000 | 0.000 | 1.449 | 0.147 | yes |
GSE39084 | 0.000 | 0.000 | −0.076 | 0.940 | no |
GSE39582 | 0.000 | 0.000 | 1.395 | 0.163 | yes |