Fig. 5

DNA replication and repair pathways are dysregulated, but housekeeping pathways are not. There are clear shifts in the expression patterns of the DNA replication and repair genes that are not apparent in other gene sets that also undergo rapid transcriptional regulation at the same points of the life-cycle. As indicated by the data from Bozdech et al. 2003, the proteasome, transcriptional machinery and translational machinery (Additional file 3) all undergo rapid changes in transcript expression levels around 6 and 24 h of the intraerythrocytic life-cycle (c) but these gene sets show consistent expression in the wild-type and mutant strains which supports the idea that the dysregulation observed in the DNA replication and repair genes is not due to time point sampling error but results from the dysregulation of k13. Grey dots represent absolute fold changes greater than 2.5. The DNA replication and repair pathways were combined into a single plot because they undergo equivalent rates of transcriptional regulation (Additional file 1: S8). The q statistic in (a) and (b) refers to the false discovery rate