Skip to main content

Table 1 KEGG pathways dysregulated in the mutant

From: Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

6 hour up-regulated KEGG pathways

24 hour down-regulated KEGG pathways

KEGG

Gene set

p.geomean

p.stat.mean

p.val

q.val

set.size

KEGG

Gene set

p.geomean

p.stat.mean

p.val

q.val

set.size

pfa03030 DNA replication

2.49E-05

4.50

1.70E-12

7.48E-11

29

pfa03030 DNA replication

5.67E-05

−4.21

2.02E-17

8.90E-16

29

pfa03430 Mismatch repair

2.83E-03

2.96

1.18E-06

2.60E-05

19

pfa03430 Mismatch repair

7.03E-03

−2.51

8.72E-08

1.92E-06

19

pfa03440 Homologous recombination

2.08E-02

2.17

2.61E-04

2.61E-03

13

pfa03440 Homologous recombination

2.61E-02

−1.86

6.82E-05

7.50E-04

16

pfa03410 Base excision repair

2.31E-02

2.05

4.57E-04

2.87E-03

16

pfa03410 Base excision repair

4.08E-02

−1.77

1.08E-04

9.48E-04

13

  1. Definitions of terms: p.geomean: geometric mean of p-values from pairwise sample comparisons. stat.mean: Average Mann Whitney U test statistic from pairwise sample comparisons. p.val: p-value for the assumption of no change in pathway regulation. q.value: False discovery rate corrected p-values. set.size: number of genes in the KEGG Gene Set