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Fig. 3 | BMC Genomics

Fig. 3

From: Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure

Fig. 3

Pathway analysis in HF-DEGs. a Venn diagram of DCM vs NF and ICM vs NF DEGs highlighting 2934 overlapping genes used in this analysis. b Top 20 enriched pathways. Bars are filled according to z-score: teal indicates higher (activated), orange indicates lower (inhibited). Pathways without a z-score are grey, and pathways with a z-score of zero are white. The ratio of the number of enriched genes to the number of total genes in the pathway is listed on the right side. c Circos plot of enriched biofunctions and their corresponding DEGs according to IPA. DEGs are colored by mean fold change from DCM or ICM vs NF. d Scatter plot of mean RPKM values of DCM against ICM logarithmically (R2 = 0.98) for the 2934 HF-DEGs

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