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Table 1 Clinical characteristics of DCM and ICM cohorts

From: Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure

Characteristics

DCM (n = 37)

ICM (n = 13)

p-value

Male sex, n (%)

30 (81)

10 (77)

0.71

Age at transplant

49 ± 13

56 ± 4

0.10

Race

 Caucasian, n (%)

31 (84)

13 (100)

0.32

 Black/African American, n (%)

3(8)

0 (0)

0.56

 unknown, n (%)

3(8)

0 (0)

0.56

Ethnicity

 Not Hispanic or Latino, n (%)

26 (70)

7 (54)

0.32

 Hispanic or Latino, n (%)

5 (14)

1 (8)

1.00

 unknown, n (%)

6 (16)

4 (31)

0.42

NYHA

3.3 ± 0.6

3.3 ± 1

0.67

aLVEF (%)

18 ± 8

13 ± 5

0.09

Comorbidities

 Coronary artery disease, n (%)

4 (11)

13 (100)

< 0.0001

 Diabetes mellitus, n (%)

6 (16)

8 (62)

0.004

 Hyperlipidemia, n (%)

8 (22)

9 (69)

0.005

aHistory of smoking, n (%)

17 (49)

8 (67)

0.33

Hypertension, n (%)

16 (43)

8 (62)

0.34

aBMI ≥ 30, n (%)

5 (16)

2(22)

0.64

Medications

 Inotropes, n (%)

11 (30)

3 (23)

0.73

 Statins, n (%)

10 (27)

12 (92)

< 0.0001

 Antiarrhythmics, n (%)

32 (86)

12 (92)

1.00

 Amiodarone, n (%)

11 (30)

3 (23)

0.73

 Aspirin, n (%)

8 (62)

15 (41)

0.22

 Beta Blockers, n (%)

20 (54)

8 (62)

0.75

 ACE inhibitor, n (%)

17 (46)

8 (62)

0.52

Device Therapy

 ICD, n (%)

32 (86)

8 (62)

0.10

 LVAD/BiVAD, n (%)

16 (43)

4 (31)

0.52

  1. aUnknown for some patients. Plus-minus values are means ± one SD. P-values determined by Mann-Whitney U Test or Fisher’s Exact Test (at significance levels of 0.05, 2-tailed hypothesis) where appropriate. ICD implantable cardioverter defibrillator, LVEF left ventricular ejection fraction, LVAD/BiVAD left/biventricular assist device, NYHA New York Heart Association