Table 4 Comparison of odd ratio means among the diplotypes that share the same allele of rs16969968 (A) GG and (B) AG, along with predicted effects on CHRNA5, CHRNA3, CHRNB4 mRNA expression
Diplotype | Percent | OR | CHRNA5 | CHRNA3 | CHRNB4 |
|---|---|---|---|---|---|
A. Diplotype with rs16969968 = GG | |||||
AGGC-GGGG | 2 | 0.82 | medium | low | medium |
AGAC-GGGG | 8 | 1.00 | medium | medium | medium |
GGGC-GGGG | 2 | 1.04 | low | low | medium |
GGGG-GGGG | 2 | 1.07 | low | low | low |
AGAC-GGGC | 4 | 1.08 | medium | medium | high |
AGAC-AGGC* | 5 | 1.18 | high | medium | high |
AGAC-AGAC*# | 8 | 1.63 | high | high | high |
B. Diplotype with rs16969968 = AG | |||||
AGAC-GAGG | 5 | 0.86 | medium | medium | medium |
GAGC-GGGC | 4 | 1.05 | low | low | high |
GAGC-GGGG | 8 | 1.32 | low | low | medium |
AGAC-GAGC+ | 18 | 1.62 | medium | medium | high |
AGGG-GAGC+ | 3 | 1.62 | medium | high | medium |
AGGC-GAGC+ | 5 | 1.68 | medium | low | high |