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Table 4 Examples of substrate annotation ranking

From: Combining multiple functional annotation tools increases coverage of metabolic annotation

Rank Substrate Examples
1 Metabolite that can be incorporated as a transport reaction in a metabolic model • Fe
• lysine
2 Substrate(s) that map to a small number of possible transport reactions • Mg/Co/Ni
• aromatic amino acid
3 Broader substrate classes not directly usable to construct a metabolic network • dipeptide
• sugar
4 Very broad class of substrates • multidrug efflux
• protein
5 No substrate annotated  
  1. Transporter substrates were ranked from most specific (rank 1) to least specific (no substrate, rank 5). See Additional file 3 for the full table