Fig. 2

lncRNAs are enriched near genes that are important for heart development. a Classification of the lncRNA candidates found in the screen. Heart-selective lncRNAs are less likely to be bidirectional or antisense lncRNAs. Some lncRNAs were judged to be both antisense and bidirectional due to alternative promoter isoforms. b Distribution of the Pearson correlation coefficients between the bidirectional promoter pairs over the course of development. The arrow indicates a negative correlation and the arrowhead indicates a positive correlation. c Hand1 shows a correlated expression pattern with its bidirectional lncRNA (left), while Sall4 exhibits the opposite trend (right). d The proportion of genes that possess bidirectional lncRNAs in the mouse were examined by referring to RefSeq and a paper that identified haploinsufficient genes. Bidirectional lncRNAs were significantly enriched among haploinsufficient genes