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Table 1 Impact of Whole Genome Sequencing on the Categorization of Outbreak-Related Isolates

From: Evaluation of whole-genome sequencing for outbreak detection of Verotoxigenic Escherichia coli O157:H7 from the Canadian perspective

Outbreak

Number of Cases Identified by PFGE/MLVA

Number of Cases Identified by WGS

Number of Additional Cases Included by WGS Onlyc

Number of Cases Excluded by WGS

1

14

14

0

0

2

2

3

1

0

3

15

13

0

2b

4

23

24a

0

0

5

18

18

0

0

6

9

6

1

4b

7

31

31

0

0

8

28

28

0

0

  1. PFGE pulsed-field gel electrophoresis, MLVA multilocus variable-number tandem-repeat analysis, WGS whole genome sequencing
  2. aIsolate ruled in by WGS also demonstrated a related MLVA profile
  3. bIsolates were associated with a suspected multi-strain event; may represent genetic variants for which no clinical/non-clinical match was identified
  4. cIsolates were not previously identified as related by PFGE and/or MLVA