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Table 1 Impact of Whole Genome Sequencing on the Categorization of Outbreak-Related Isolates

From: Evaluation of whole-genome sequencing for outbreak detection of Verotoxigenic Escherichia coli O157:H7 from the Canadian perspective

Outbreak Number of Cases Identified by PFGE/MLVA Number of Cases Identified by WGS Number of Additional Cases Included by WGS Onlyc Number of Cases Excluded by WGS
1 14 14 0 0
2 2 3 1 0
3 15 13 0 2b
4 23 24a 0 0
5 18 18 0 0
6 9 6 1 4b
7 31 31 0 0
8 28 28 0 0
  1. PFGE pulsed-field gel electrophoresis, MLVA multilocus variable-number tandem-repeat analysis, WGS whole genome sequencing
  2. aIsolate ruled in by WGS also demonstrated a related MLVA profile
  3. bIsolates were associated with a suspected multi-strain event; may represent genetic variants for which no clinical/non-clinical match was identified
  4. cIsolates were not previously identified as related by PFGE and/or MLVA