Fig. 1

Co-splicing correlations of APP with UBQLN1 and SSC5D in hippocampus (GTEx). a Equalizer type plot displaying the exon count distributions of APP ranked across individuals at each exon, with maximum possible ranking for tie. Colors follow the ranking of exon 1 of APP. b The subject ranking of exon count distributions of UBQLN1, colored by the ranking of APP exon 1, shows a clear coherence between a and b. The tuning of exon count distributions between genes leads to similar distance matrices between individuals and results in high Mantel’s correlations. c For SSC5D the ranking coherence is broken, Mantel’s correlation is therefore low and there is no co-splicing with APP. d The first principal component (PC), across individuals, of the exon count distributions of APP highly correlates with that of UBQLN1, adjusting for covariates. e The first PC of APP does not correlate with the first PC of SSC5D, suggesting low splicing coregulation