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Table 1 Genes with significant APP co-splicing between studies (GTEx and BRAINEAC) and different brain regions (HIPP: hippocampus, AMYG: amygdata, HYP: hypotalamus, ACTX: anterior cingulate cortex, CTX: cortex, FCTX: frontal cortex, OCTX: occipital cortex, TCTX: temporal cortex)

From: When pitch adds to volume: coregulation of transcript diversity predicts gene function

Genes GTEx BRAINEAC
HIPP PCA-cor (P) HIPP M-cor (P) AMYG M-cor (P) HYP M-cor (P) ACTX M-cor (P) CTX M-cor (P) FCTX M-cor (P) HIPP M-cor (P) FCTX M-cor (P) OCTX M-cor (P) TCTX M-cor (P)
DNAJC6 0.75 (1.1e-13) 0.83 (0.007) 0.84 (0.002) 0.84 (0.02) 0.89 (0.004) 0.79 (0.003) 0.91 (0.009) 0.52 (0.002) 0.32 (0.013) 0.42 (0.006) 0.3 (0.038)
DNER 0.71 (9.0e-12) 0.75 (0.019) 0.71 (0.014) 0.85 (0.017) 0.81 (0.014) 0.65 (0.018) 0.8 (0.039) 0.38 (0.022) 0.31 (0.015) 0.34 (0.027) 0.35 (0.019)
UBQLN1 0.69 (6.6e-11) 0.83 (0.007) 0.73 (0.01) 0.82 (0.026) 0.75 (0.027) 0.72 (0.008) 0.8 (0.039) 0.52 (0.002) 0.52 (1e-4) 0.44 (0.004) 0.48 (0.002)
ATP6AP2 0.68 (9.0e-11) 0.82 (0.008) 0.82 (0.003) 0.86 (0.015) 0.87 (0.006) 0.75 (0.006) 0.92 (0.008) 0.48 (0.004) 0.35 (0.007) 0.43 (0.005) 0.32 (0.028)
APLP2 0.68 (1.9e-10) 0.77 (0.016) 0.59 (0.047) 0.75 (0.048) 0.76 (0.025) 0.67 (0.014) 0.81 (0.037) 0.42 (0.012) 0.39 (0.003) 0.42 (0.006) 0.43 (0.004)
TPD52 0.66 (6.0e-10) 0.79 (0.013) 0.75 (0.008) 0.81 (0.028) 0.82 (0.012) 0.7 (0.01) 0.9 (0.011) 0.4 (0.018) 0.32 (0.013) 0.43 (0.005) 0.36 (0.016)
PRKAR1A 0.64 (3.3e-09) 0.8 (0.011) 0.81 (0.003) 0.78 (0.038) 0.8 (0.016) 0.72 (0.008) 0.83 (0.03) 0.41 (0.015) 0.29 (0.022) 0.34 (0.029) 0.36 (0.014)
ACLY 0.63 (5.1e-09) 0.79 (0.013) 0.7 (0.016) 0.79 (0.035) 0.88 (0.004) 0.73 (0.006) 0.89 (0.013) 0.5 (0.003) 0.31 (0.017) 0.46 (0.002) 0.4 (0.007)
ATP2A2 0.58 (2.0e-07) 0.81 (0.009) 0.77 (0.006) 0.77 (0.042) 0.8 (0.016) 0.8 (0.002) 0.82 (0.031) 0.5 (0.003) 0.37 (0.004) 0.35 (0.021) 0.37 (0.012)
STAU1 0.56 (6.5e-07) 0.77 (0.016) 0.7 (0.016) 0.79 (0.033) 0.8 (0.015) 0.69 (0.011) 0.81 (0.037) 0.41 (0.015) 0.44 (0.001) 0.44 (0.004) 0.44 (0.004)
MTMR4 0.51 (6.2e-06) 0.74 (0.022) 0.64 (0.029) 0.77 (0.042) 0.81 (0.014) 0.62 (0.023) 0.87 (0.018) 0.41 (0.016) 0.34 (0.008) 0.35 (0.021) 0.32 (0.029)
  1. The first column shows the co-splicing correlations obtained by the PC method and corresponding P-values in parenthesis. Mantel’s correlations follow from the second column