Skip to main content

Table 1 Genes with significant APP co-splicing between studies (GTEx and BRAINEAC) and different brain regions (HIPP: hippocampus, AMYG: amygdata, HYP: hypotalamus, ACTX: anterior cingulate cortex, CTX: cortex, FCTX: frontal cortex, OCTX: occipital cortex, TCTX: temporal cortex)

From: When pitch adds to volume: coregulation of transcript diversity predicts gene function

Genes

GTEx

BRAINEAC

HIPP PCA-cor (P)

HIPP M-cor (P)

AMYG M-cor (P)

HYP M-cor (P)

ACTX M-cor (P)

CTX M-cor (P)

FCTX M-cor (P)

HIPP M-cor (P)

FCTX M-cor (P)

OCTX M-cor (P)

TCTX M-cor (P)

DNAJC6

0.75 (1.1e-13)

0.83 (0.007)

0.84 (0.002)

0.84 (0.02)

0.89 (0.004)

0.79 (0.003)

0.91 (0.009)

0.52 (0.002)

0.32 (0.013)

0.42 (0.006)

0.3 (0.038)

DNER

0.71 (9.0e-12)

0.75 (0.019)

0.71 (0.014)

0.85 (0.017)

0.81 (0.014)

0.65 (0.018)

0.8 (0.039)

0.38 (0.022)

0.31 (0.015)

0.34 (0.027)

0.35 (0.019)

UBQLN1

0.69 (6.6e-11)

0.83 (0.007)

0.73 (0.01)

0.82 (0.026)

0.75 (0.027)

0.72 (0.008)

0.8 (0.039)

0.52 (0.002)

0.52 (1e-4)

0.44 (0.004)

0.48 (0.002)

ATP6AP2

0.68 (9.0e-11)

0.82 (0.008)

0.82 (0.003)

0.86 (0.015)

0.87 (0.006)

0.75 (0.006)

0.92 (0.008)

0.48 (0.004)

0.35 (0.007)

0.43 (0.005)

0.32 (0.028)

APLP2

0.68 (1.9e-10)

0.77 (0.016)

0.59 (0.047)

0.75 (0.048)

0.76 (0.025)

0.67 (0.014)

0.81 (0.037)

0.42 (0.012)

0.39 (0.003)

0.42 (0.006)

0.43 (0.004)

TPD52

0.66 (6.0e-10)

0.79 (0.013)

0.75 (0.008)

0.81 (0.028)

0.82 (0.012)

0.7 (0.01)

0.9 (0.011)

0.4 (0.018)

0.32 (0.013)

0.43 (0.005)

0.36 (0.016)

PRKAR1A

0.64 (3.3e-09)

0.8 (0.011)

0.81 (0.003)

0.78 (0.038)

0.8 (0.016)

0.72 (0.008)

0.83 (0.03)

0.41 (0.015)

0.29 (0.022)

0.34 (0.029)

0.36 (0.014)

ACLY

0.63 (5.1e-09)

0.79 (0.013)

0.7 (0.016)

0.79 (0.035)

0.88 (0.004)

0.73 (0.006)

0.89 (0.013)

0.5 (0.003)

0.31 (0.017)

0.46 (0.002)

0.4 (0.007)

ATP2A2

0.58 (2.0e-07)

0.81 (0.009)

0.77 (0.006)

0.77 (0.042)

0.8 (0.016)

0.8 (0.002)

0.82 (0.031)

0.5 (0.003)

0.37 (0.004)

0.35 (0.021)

0.37 (0.012)

STAU1

0.56 (6.5e-07)

0.77 (0.016)

0.7 (0.016)

0.79 (0.033)

0.8 (0.015)

0.69 (0.011)

0.81 (0.037)

0.41 (0.015)

0.44 (0.001)

0.44 (0.004)

0.44 (0.004)

MTMR4

0.51 (6.2e-06)

0.74 (0.022)

0.64 (0.029)

0.77 (0.042)

0.81 (0.014)

0.62 (0.023)

0.87 (0.018)

0.41 (0.016)

0.34 (0.008)

0.35 (0.021)

0.32 (0.029)

  1. The first column shows the co-splicing correlations obtained by the PC method and corresponding P-values in parenthesis. Mantel’s correlations follow from the second column