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Table 2 KEGG pathways enriched in co-splicing with APP in GTEx and BRAINEAC, across limbic and neocortex regions

From: When pitch adds to volume: coregulation of transcript diversity predicts gene function

STUDY KEGG Pathway Description corrected P
GTEx hsa04070 Phosphatidylinositol signaling system 8.93E-4
hsa04728 Dopaminergic synapse 8.93E-4
hsa04141 Protein processing in endoplasmic reticulum 4.04E-3
hsa04120 Ubiquitin mediated proteolysis 5.32E-3
hsa04022 cGMP-PKG signaling pathway 6.82E-3
hsa04730 Long-term depression 1.46E-2
hsa04530 Tight junction 1.65E-2
hsa04724 Glutamatergic synapse 1.67E-2
hsa04520 Adherens junction 1.80E-2
hsa04713 Circadian entrainment 2.28E-2
hsa04723 Retrograde endocannabinoid signaling 2.36E-2
hsa04261 Adrenergic signaling in cardiomyocytes 3.18E-2
hsa04721 Synaptic vesicle cycle 3.34E-2
hsa04727 GABAergic synapse 3.34E-2
hsa05130 Pathogenic Escherichia coli infection 3.47E-2
hsa04114 Oocyte meiosis 4.75E-2
hsa04611 Platelet activation 4.75E-2
hsa04015 Rap1 signaling pathway 4.75E-2
hsa04720 Long-term potentiation 4.94E-2
BRAINEAC hsa4142 Lysosome 1.82E-9
hsa4721 Synaptic vesicle cycle 1.46E-6
hsa4961 Endocrine and other factor-regulated calcium reabsorption 6.20E-6
hsa4141 Protein processing in endoplasmic reticulum 3.62E-4
hsa5110 Vibrio cholerae infection 8.07E-4
hsa4144 Endocytosis 1.04E-3
hsa4261 Adrenergic signaling in cardiomyocytes 2.65E-3
hsa4114 Oocyte meiosis 1.00E-2
hsa4720 Long-term potentiation 1.00E-2
hsa4145 Phagosome 1.20E-2
hsa4120 Ubiquitin mediated proteolysis 1.28E-2
  1. P-values are corrected for the number of pathways tested (277) and brain regions. Pathways in bold face were validated between studies