Table 2 KEGG pathways enriched in co-splicing with APP in GTEx and BRAINEAC, across limbic and neocortex regions

GTEx

hsa04070

Phosphatidylinositol signaling system

8.93E-4

hsa04728

Dopaminergic synapse

8.93E-4

hsa04141

Protein processing in endoplasmic reticulum

4.04E-3

hsa04120

Ubiquitin mediated proteolysis

5.32E-3

hsa04022

cGMP-PKG signaling pathway

6.82E-3

hsa04730

Long-term depression

1.46E-2

hsa04530

Tight junction

1.65E-2

hsa04724

Glutamatergic synapse

1.67E-2

hsa04520

Adherens junction

1.80E-2

hsa04713

Circadian entrainment

2.28E-2

hsa04723

Retrograde endocannabinoid signaling

2.36E-2

hsa04261

Adrenergic signaling in cardiomyocytes

3.18E-2

hsa04721

Synaptic vesicle cycle

3.34E-2

hsa04727

GABAergic synapse

3.34E-2

hsa05130

Pathogenic Escherichia coli infection

3.47E-2

hsa04114

Oocyte meiosis

4.75E-2

hsa04611

Platelet activation

4.75E-2

hsa04015

Rap1 signaling pathway

4.75E-2

hsa04720

Long-term potentiation

4.94E-2

BRAINEAC

hsa4142

Lysosome

1.82E-9

hsa4721

Synaptic vesicle cycle

1.46E-6

hsa4961

Endocrine and other factor-regulated calcium reabsorption

6.20E-6

hsa4141

Protein processing in endoplasmic reticulum

3.62E-4

hsa5110

Vibrio cholerae infection

8.07E-4

hsa4144

Endocytosis

1.04E-3

hsa4261

Adrenergic signaling in cardiomyocytes

2.65E-3

hsa4114

Oocyte meiosis

1.00E-2

hsa4720

Long-term potentiation

1.00E-2

hsa4145

Phagosome

1.20E-2

hsa4120

Ubiquitin mediated proteolysis

1.28E-2