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Table 4 Common genes differentially expressed in two comparisons: group I vs group II and group I vs group II + III + IV, related to human disease: NAFLD-Non Alcoholic Fatty Liver Disease, NASH –Non-Alcoholic SteatoHepatitis, OB-obesity, CAD-Cardiovascular Disease, T1D – diabetes Mellitus type I, T2DM – Diabetes Melitus type II, ND-Neurodegenarative Disease, ID – Immunity Disease

From: Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases

Regulation by cDDGS

official gene symbol

official gene name

Disease

up

KAT8

lysine acetyltransferase 8

NAFLD, NASH, cancer [43, 44]

up

CYGB

cytoglobin

OB,CAD, cancer [45, 46]

up

GIMAP4

GTPase, IMAP family member 4

T1D, ID [47]

up

HIP1R

huntingtin interacting protein 1 related

ND [48]

up

CEP128

centrosomal protein 128

 

up

FAM105A

family with sequence similarity 105, member A

T2D [49]

up

PCDH12

protocadherin 12

CAD [50]

up

C5AR1

complement component 5a receptor 1

OB, ND, CAD [41, 42, 51]

up

ZMAT1

zinc finger matrin-type 1

 

up

VSIG4

V-set and immunoglobulin domain containing 4

OB, ID [52]

up

SP110

SP110 nuclear body protein

ID [53]

up

SPARCL1

SPARC like 1

OB, CAD, ND, cancer [54,55,56]

up

TCHP

trichoplein keratin filament binding

 

up

DSPP

dentin sialophosphoprotein

 

up

MS4A2

membrane spanning 4-domains A2

ND, allergy

up

MYO1E

myosin IE

ND [57]

up

NCOA7

nuclear receptor coactivator 7

 

up

RGS1

regulator of G protein signaling 1

CAD [58]

up

ZEB1

zinc finger E-box binding homeobox 1

OB, CAD [17, 18]

down

FASN

fatty acid synthase

OB, T2D, NAFLD, cancer [19, 20, 59]

down

SLC25A1

solute carrier family 25 member 1

cancer, T2D, ND [60]

down

HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1

OB, T2D, CAD [61]

down

ALAS1

5′-aminolevulinate synthase 1

OB, NAFLD, CAD, T2D, ND [62, 63]

down

RTN3

reticulon 3

T2D,CAD, ND [64, 65]

down

AACS

acetoacetyl-CoA synthetase

NAFLD, ND [66, 67]

down

ARVCF

ARVCF, delta catenin family member

CAD [68]

down

UMPS

uridine monophosphate synthetase

OB, cancer [69,70,71]

down

NDUFB8

NADH:ubiquinone oxidoreductase subunit B8

 

down

TAF4B

TATA-box binding protein associated factor 4b

 

down

GFM1

G elongation factor mitochondrial 1

 

down

NDUFS5

NADH:ubiquinone oxidoreductase subunit S5

 

down

PDHX

pyruvate dehydrogenase complex component X

T2D, ND [72]

down

CYP2U1

cytochrome P450 family 2 subfamily U member 1

 

down

FITM2

fat storage-inducing transmembrane protein 2

OB. [73]