Fig. 2

Summary results for microarray analyses. Venn diagrams in panel (a) display the differentially expressed transcripts found in common among treatments based on matching RefSeq Accession IDs. Hierarchical clustering analyses (b) identifed relationships based on significant differential transcript expression among treatment combinations for each exposure. Transcripts differentially expressed in common among repeated experimental exposures (c) and correlations in expression among these transcripts (d) provided opportunities for assessing reproducibility of experimental results. Note that no correlation was calculated for Diet given that only two targets were found in common. Key for Venn Diagrams: Exp = Exposures 1–3, Diet = food level, and Mal = malaria treatment. For hierarchical clustering analysis: infected = malaria infection, restricted = restricted diet and the values 0, 5, 10 and 20 = TNT dosing levels in mg/kg-d