Treatments
|
Significant Annotation Clusters
|
Cluster ID
|
Enrichment Score
|
Top Clusters - Enriched Function (Summary of Cluster Components)
|
Categorical Match 1 - Enriched Function Summary Response
|
Categorical Match 2 - Cluster to Toxicological Phenotype
|
TNT
|
18
|
C1
|
2.14
|
proteolysis, peptidase activity, serine hydrolase activity
|
Protein Catabolism
|
↓: ALB, GLOB, TP, & TS
|
|
C2
|
1.74
|
carbohydrate biosynthesis processes
|
Carbohydrate Storage
|
↓ Body Weight
|
|
C3
|
1.55
|
lipid transport, lipid localization, lipoprotein metabolism, extracellular
|
Lipid Metabolism
|
↓ Body Weight, ↑ Liver Wt.
|
|
C4
|
1.42
|
glycolysis, carbohydrate catabolic process, glucose catabolic process
|
Carbohydrate to Cellular Energy
|
↓ Body Weight; ↓ Feeding
|
|
C5
|
1.26
|
hemostasis, blood coagulation, wound healing, endopeptidase activity
|
RBC Retention & Wound Healing
|
↓: Hb, Hct, RBC & MCHC; ↑ spleen wt.
|
Diet
|
2
|
C1
|
1.12
|
mitochondrion, mitochondrial envelope
|
Cellular energy production
|
↓ Body Weight; ↓ Inguinal fat
|
|
C2
|
0.51
|
calcium binding, cation binding, metal binding
|
Cell signaling
|
–
|
INI x Diet
|
0
|
–
|
–
|
–
| | |
Exposure 2 (Malaria Infection x Diet)
|
Malaria
|
9
|
C1
|
2.57
|
positive regulation of T cell, lymphocyte & leukocyte activation. Regulation of immune system process, regulation of programmed cell death
|
Immune Response
|
↑: WBC, Lympho, Mono; ↓ H/L
|
|
C2
|
1.42
|
zinc finger - RING-type, zinc finger C3HC4 RING-type
|
Immune Response
|
↑: WBC, Lympho, Mono; ↓ H/L
|
|
C3
|
1.10
|
zinc finger - C2H2, cation binding
|
Immune Response
|
↑: WBC, Lympho, Mono; ↓ H/L
|
|
C4
|
1.02
|
apoptosis, programmed cell death
|
Immune Response
|
↑ WBCs
|
|
C5
|
0.60
|
immunoglobulin-like, signal peptide
|
Immune Response
|
↑ WBCs
|
Diet
|
10
|
C1
|
1.14
|
cofactor binding, coenzyme binding, oxidation reduction
|
Electron Iransport, Energy Production
|
↓ Feeding; ↓: WBC, Lympho, H/L
|
|
C2
|
1.04
|
plasma lipoprotein particle, protein-lipid complex, extracellular space
|
Lipid Metabolism
|
↓ Feeding; ↓: WBC, Lympho, H/L
|
|
C3
|
0.86
|
endoplasmic reticulum membrane, endomembrane system
|
Cellular & endomembrane transport
|
–
|
|
C4
|
0.80
|
mitochondrion, mitochondrial envelope
|
Cellular energy production
|
↓ Feeding; ↓: WBC, Lympho, H/L
|
|
C5
|
0.54
|
organelle lumen, membrane-enclosed lumen - Nested in Mitrochnodria
|
Cellular energy production
|
↓ Feeding; ↓: WBC, Lympho, H/L
|
Malaria x Diet
|
1
|
C1
|
0.71
|
zinc ion binding, cation binding
|
Immune Response
|
Malaria: ↑ WBCs & Lympho; Diet: ↓ WBCs & Lympho
|
Exposure 3 (TNT x Malaria Infection)
|
TNT
|
10
|
C1
|
1.54
|
ribonucleoprotein complex biogenesis, rRNA processing
|
Ribosomal Function
|
–
|
|
C2
|
1.49
|
homeostatic process, membrane fraction
|
PPAR Signaling, Lipid Metab.
|
↓ Body Weight, ↑ Liver Wt.
|
|
C3
|
1.15
|
vesicle-mediated transport, endocytosis
|
Intracellular transport, Immune Sys.
|
↑ WBCs
|
|
C4
|
1.11
|
WD40 repeat, RNA processing, ribonucleoprotein complex
|
Transcriptional Reg., Signal Trans.
|
–
|
|
C5
|
0.85
|
proteolysis, protein catabolic process, endopeptidase activity
|
Protein Catabolism
|
↓ Body Weight
|
Malaria
|
0
|
–
|
–
|
–
| | |
TNT x iviaiaria
|
0
|
–
|
–
|
–
| | |