Table 2 Summary of stressor phenotypes from McFarland et al. [1] putatively matched to corresponding differentially expressed transcripts. Explanation of matches are provided in the Discussion text
Stressor Phenotype | Transcriptional | Â | Â | Gene |
|---|---|---|---|---|
Expression | Gene Transcript | Accession # | Symbol | |
Effects of TNT Exposure | ||||
 Effects on Blood Homeostasis: | ||||
  Decreased mean corpuscular hemoglobin concentration (MCHC) | Increased | ELG 9 homolog 3 | XP-421233.2 | E3LN3 |
  Anemia (Decreased RBCs) | Increased | hemoglobin alpha, adult chain 2 | NP-037228 | Hba1 |
Increased | hemoglobin subunit alpha-D | NP-001004375 | HBAD | |
Increased | erythrocyte membrane protein band 4.1-like 2 | XP-002192849 | Â | |
Decreased | coagulation factor IX | NP-989674.1 | F9 | |
Increased | cathepsin D precursor | NP-990508 | CTSD | |
Increased | chitotriosidase | XP-001518594 | Â | |
 Energy Metabolism and Body Weight: | ||||
  Hormesis - Increase in low TNT; decreased at high TNT | Decreased | apolipoprotein A-I precursor | NP-990856.1 | APOA1 |
Decreased | apolipoprotein A-V | XP-417939.2 | APOA5 | |
Decreased | apolipoprotein B | NP-001038098.1 | APOB | |
Increased | chitotriosidase | XP-001518594 | Â | |
Increased | pyruvate kinase | NP-990800.1 | FKM | |
Increased | glucose phosphate isomerase | NP-001006128.1 | GPI | |
Increased | ubiquitin carboxyl-terminal esterase L1 | NP-001073681.1 | UCHL1 | |
Increased | ubiquitin specific protease 4 | NP-001006134.1 | USP4 | |
Increased | CNDP dipeptidase 2 | NP-001006385.1 | CNDP2 | |
Increased | peroxisome proliferative activated receptor y | XP-416082.2 | Â | |
Effects of Malaria Infection | ||||
 Immune Response: | ||||
  Increased WBCs, Lymphocytes & Monocytes | Increased | major histocompatibility complex (MHC) | NP-032235.1 | Mr1 |
  Increased spleen size | Increased | CD74 molecule MHC class II invariant | NP-001001613.1 | CD74 |
Increased | T-cell co-stimulator | NP-001093758.1 | ICOS | |
Increased | linker for activation of T-cells family member 2 | NP-001007483.1 | LAT2 | |
Increased | T-cell surface glycoprotein CD3 epsilon chain precursor | NP-996787.1 | CD3E | |
Increased | glutathione peroxidase 1 | NP-001130041.1 | GPX1 | |
Increased | CD8 antigen alpha polypeptide | NP-990566.1 | CD8A | |
Increased | interferon regulatory factor 1 | NP-001152868.1 | Irf 1 | |
Increased | interferon regulatory factor 1 isoform a | XP-002188628.1 | Â | |
Increased | interferon-gamma-inducible p47 GTPase | XP-001377372.1 | Â | |
Increased | pyruvate kinase | NP-990800.1 | PKM | |
Increased | glucose-6-phosphate 1-dehydrogenase | NP-058702.1 | G6pd | |
Increased | interferon-gamma | XP-001377372.1 | Â | |
Increased | interleukin 2 receptor | NP-990197.1 | BCL2A1 | |
Effects of Food Limitation | ||||
 Systemic Cellular Energy: | ||||
  Decreased Body Weight | Decreased | NADH dehydrogenase: ubiquinone | NP-001006518.1 | NDUFS1 |
  Decreased inguinal fat, brain and testes weights | Decreased | short-chain acyl-CoA dehydrogenase | NP-001006193.1 | ACADS |
  Decreased Albumin and Choleserol | Decreased | ATP synthase | XP-422453.1 | ATPAF1 |
Increased | peroxisome proliferator-activated receptor binding protein | XP-418125.2 | MED1 | |
Increased | apolipoprotein A-I precursor | NP-990856.1 | APOA1 | |
 Immune Response: | ||||
  Decreased WBCs, Lymphocytes, Eosinophils & Basophils | Generalized Responses | diminished energy and/or general stressor mediated decrements to standing immunity |  |  |
Interactive Effects -TNT and Food Limitation | ||||
 Body Weight Change and Inguinal Fat Bodies | ||||
  TNT-induced hormesis on body weight was abolished under food restriction. | TNT Increase (nullified) | annexin A1 | NP-996789.1 | ANXA1 |
TNT Increase (nullified) | annexin A2 | NP-990682.1 | ANXA2 | |
  Reduced inguinal fat in food-restricted lizards was abolished by TNT exposure. | Decrease (enhanced) | apolipoprotein A-I precursor | NP-990856.1 | APOA1 |
Decrease (enhanced) | apolipoprotein B | NP-001038098.1 | APOB | |
Interactive Effects - Malaria Infection and Food Limitation | ||||
 WBCs /Immune Response - | ||||
  Decreased WBCs & Lymphocytes under food limitation were | Increased (enhanced) | CD74 molecule MHC class II invariant | NP-001001613.1 | CD74 |
  increased up to ad libitum levels under malaria infection | Increased (enhanced) | T-cell co-stimulator | NP-001093758.1 | ICOS |
Increased (enhanced) | linker for activation of T-cells family member 2 | NP-001007483.1 | LAT2 | |
Increased (enhanced) | T-cell surface glycoprotein CD3 epsilon chain precursor | NP-996787.1 | CD3E | |
Increased (enhanced) | CD8 antigen alpha polypeptide | NP-990566.1 | CD8A | |
Increased (enhanced) | interferon regulatory factor 1 | NP-001152868.1 | Irf 1 | |
Increased (enhanced) | interferon regulatory factor 1 isoform a | XP-002188628.1 | Â | |
Increased (enhanced) | interferon-gamma-inducible p47 GTPase | XP-001377372.1 | Â | |
Increased (enhanced) | interferon-gamma | XP-001377372.1 | Â | |
Increased (enhanced) | interleukin 2 receptor | NP-990197.1 | BCL2A1 | |
Interactive Effects - TNT and Malaria Infection | ||||
 WBCs /Immune Response | ||||
  Both TNT and Malaria caused increased WBCs | Increased (enhanced) | B-cell linker protein | NP-990239.1 | BLNK |
Increased (enhanced) | T-cells family member 2 | NP-001007483.1 | LAT2 | |
 Testes Size | ||||
  TNT x Malaria reduce testes size nearly 70% - No testes expression, but systemic energy effects | Decreased | apolipoprotein A-I precursor | NP-990856.1 | APOA1 |