Fig. 3

Reduced InR signaling impacts different pathways and functional gene groups in males and females. The GO Biological Process category (top) and KEGG pathway (bottom) with the most significant changes are shown for male (left) and female (right). The p-value is indicated by the red-purple scale, with red being most significant. The number of genes that were considered in the analyses is plotted on the X-axis. Pathways and groups that are uniquely significant in one sex are indicated by green font (FDR < 0.05)