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Table 2 Evolved expression changes in response to selection for enhanced associative learning ability. Thirty-six transcripts, expressed from 34 loci, showed evidence of evolved expression regulation that was consistent across four replicate pairs of lines, as identified by three complementary methods (see Methods and Additional file 8). Transcripts are in order of increasing Fold Change, with high Fold Change indicating elevated expression in selected lines

From: Regulatory and sequence evolution in response to selection for improved associative learning ability in Nasonia vitripennis

gene name gene accession transcript accession log2 Fold Change edgeR Padj pairwise tests Padj PCA correlation ρpearson P
Rho GTPase-activating proteinb LOC100118685b XM_008205242.1b -3 0 0 0.8 0
molybdenum cofactor biosynthesis protein 1 LOC100118555 XM_008212104.1 −2.6 0 0 0.7 0.02
uncharacterised protein (LOC100679965) LOC100679965 XM_008216564.1 −2.6 0 1 0.3 0.18
circadian locomoter output cycles protein kaput LOC100114103 XM_008216217.1 −2.2 0 0.09 0.5 0.06
serine/threonine-protein kinase MST4 LOC100121999 XM_008213253.1 −2.2 0 0 0.7 0.01
uncharacterized protein (LOC100678681) LOC100678681 XM_003425395.2 −2.1 0.83 0.43 0.6 0.02
cytochrome b5 reductase 4 LOC100117767 XM_008209788.1 −2.1 0.74 0 0.2 0.27
protein split ends-like LOC100123328 XM_008214414.1 −2 0 0 0.2 0.22
small subunit processome component 20 homolog LOC100122027 XM_008212760.1 −1.9 0 0 0.3 0.16
specific mRNA (nucleoside-2’-O-)-methyltransferase 2a LOC103315388a XM_008203871.1a − 1.8 0.01 0.6 0.6 0.02
mitochondrial 2-oxoglutarate/malate carrier protein-like LOC100121662 XM_008219522.1 −1.4 0.06 0.02 0.6 0.02
G2/M phase-specific E3 ubiquitin-protein ligase LOC100115982 XM_008205146.1 −1.4 0.99 0.01 0.2 0.3
60 kDa heat shock protein, mitochondrial-like LOC100114031 XM_001599995.3 −1.4 0.02 0 0.7 0.01
sodium- and chloride-dependent GABA transporter ine LOC100115303 XM_008210619.1 −1.4 0.4 0.01 0.2 0.31
F-box protein 11 LOC100115478 XR_512626.1 −1.2 1 0 0.1 0.4
lisH domain and HEAT repeat-containing protein KIAA1468 homolog LOC100120301 XM_008213739.1 −1.2 0.94 0.09 0.7 0.01
DNA topoisomerase 2 LOC100117297 XM_008208620.1 −1.1 1 1 0.7 0.01
aspartylglucosaminidase LOC100119424 XM_008213772.1 −1.1 0.43 0 0.1 0.39
putative gamma-glutamylcyclotransferase CG2811 LOC100122076 XM_008213266.1 −1 0.11 0 0.7 0.01
AT-rich interactive domain-containing protein 2 LOC100121989 XM_008218909.1 −1 1 1 0.7 0.01
solute carrier family 12 member 4 LOC100116848 XM_008210249.1 −1 0.53 0.04 0.2 0.21
uncharacterised protein (LOC100120958) LOC100120958 XM_008211884.1 −1 0.55 0 0.5 0.05
protein argonaute-2-like LOC100123519 XM_008216662.1 1.1 0.03 0 0.3 0.15
paired box protein Pax-6 LOC100118963 XM_001602773.3 1.1 0.05 0.02 0.1 0.51
ectonucleoside triphosphate diphosphohydrolase 5 LOC100678150 XM_008211788.1 1.1 0.04 0 0.6 0.03
coiled-coil domain-containing protein 149 LOC100122426 XM_008206132.1 1.1 1 0.01 0.7 0.02
carbohydrate sulfotransferase 5-like LOC100116691 XM_001601071.3 1.3 0.02 0 0.3 0.17
putative tyrosine-protein kinase Wsck LOC100677925 XM_008204866.1 1.3 0.28 0 0.2 0.21
golgin subfamily A member 2-like LOC100116846 XM_008209761.1 1.4 0.03 0.42 0.5 0.04
uncharacterized protein C10orf118 homolog LOC100121426 XM_008204491.1 1.4 0 1 0.2 0.29
diacylglycerol kinase eta LOC100120935 XM_008212357.1 1.7 0.03 0.38 0.5 0.06
dipeptidyl peptidase 9 LOC100123733 XM_008209082.1 1.8 0.02 0 0.3 0.15
decaprenyl-diphosphate synthase subunit 1 LOC100118369 XM_008211982.1 1.8 0 0 0.8 0.01
cap-specific mRNA (nucleoside-2’-O-)-methyltransferase 2a LOC103315388a XM_008203872.1a 1.8 0 1 0.7 0.01
Rho GTPase-activating proteinb LOC100118685b XM_001602542.3b 1.8 0.01 1 0.1 0.5
Kv channel-interacting protein 1-like LOC100121497 XM_008205258.1 2.1 0 0.14 0.5 0.05
  1. aTwo transcripts for this locus show opposite patterns of evolved expression changes
  2. bTwo transcripts for this locus show opposite patterns of evolved expression changes