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Fig. 1 | BMC Genomics

Fig. 1

From: Retrospective application of transposon-directed insertion-site sequencing to investigate niche-specific virulence of Salmonella Typhimurium in cattle

Fig. 1

Correlation of fitness scores of S. Typhimurium transposon-insertion mutants in the ileal wall and mesenteric lymph nodes and distribution of fitness scores. (a) A correlation plot showing a high degree of correlation between fitness scores of 8315 transposon-insertion mutants identified in the ileal wall and MLNs suggests that majority of mutants have similar phenotypes in both tissues. (b) Histograms of the fitness scores of mutants in the ileal wall and MLNs show that a large proportion of mutants have fitness scores approximate to zero in both tissues, suggesting that many insertions have no effect on phenotype. Based on fitting of bimodal distributions of fitness scores in the histograms, a fitness score of ≤ − 3.0 was selected as the cut-off value to define attenuation (within the yellow box)

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