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Fig. 3 | BMC Genomics

Fig. 3

From: Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming

Fig. 3

Map OSKM binding between human and mouse. a Schematic illustration of the three different groups of peaks, i.e. Syntenic Conserved (SC) binding group, Syntenic Unconserved (SU) binding group and UNsyntenic (UN) binding group. b Percentage of mouse OSKM peaks that can be mapped to human. The background is calculated by the simulation of peaks that have the same size and same number as the real peaks, and are allowed to map anywhere on the genome. c Fractional constitutions of SC, SU and UN peaks for each factor. d Percentage of SC binding events with respect to all syntenic binding events. For each factor, syntenic peaks are classified into four groups based on their peak enrichments of -log10(q-value). 0–25% are the top 25% of peaks while 75–100 are the bottom 25% of peaks. e Percentage of the three groups of peaks that contain repeat sequences. f Percentages of mouse peaks that contain specific type of mouse repeat sequences. Seven major types of repeat, i.e. DNA (DNA transposon elements), LINE (Long interspersed nuclear elements), LTR (Long terminal repeats), Retroposon (Transposons via RNA intermediates), Satellite (Satellite DNA which belongs to tandem repeats), Simple (Simple repeats) and SINE (Short interspersed nuclear elements) are calculated

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