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Table 1 The distribution of significant differentially methylated regions (DMRs) (q < 0.01) across the genome associated with diet. Numbers indicate how many 500 base pair windows overlap each genomic region, with the percent of the total significant DMRs that overlap such regions in parentheses for the female and male mice. The percent of windows across the entire genome that overlap these genomic regions is listed as a comparison, illustrating the overrepresentation of regulatory regions in the DMRs

From: A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice

Region

Female DMRs

Male DMRs

Whole Genome

Enhancer

237 (10.0%)

180 (11.7%)

3.5%

CTCF Binding Site

157 (6.7%)

55 (3.6%)

1.7%

TF binding site

33 (1.4%)

12 (0.8%)

0.3%

Promoter Flanking Region

795 (33.8%)

522 (33.9%)

8.1%

Promoter

370 (15.7%)

215 (14.0%)

4.5%

Exon

598 (25.4%)

415 (27.0%)

7.5%

Intergenic

748 (31.8%)

471 (30.6%)

58.6%