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Table 1 Overview of genomic alterations observed after acquisition of resistance to amoxicillin, enrofloxacin, kanamycin, or tetracycline in wild-type (for the first exposure) or in strains with previously acquired resistance to amoxicillin (AMXR), enrofloxacin (ENROR), kanamycin (KANR), or tetracycline (TETR) (for the second exposure)

From: Genome rearrangements in Escherichia coli during de novo acquisition of resistance to a single antibiotic or two antibiotics successively

 

+ amoxicillin

+ enrofloxacin

+ kanamycin

+ tetracycline

WT

ENROR

KANR

TETR

WT

AMXR

KANR

TETR

WT

AMXR

ENROR

TETR

WT

AMXR

ENROR

KANR

Amplifications

 ampC

2/2

4/4

4/4

4/4

            

Deletions

 clpS-clpA

       

1/4

  

1/3

1/4

    

 yaiT-yaiW

          

1/3

     

 slyA-nemA

   

1/4

            

 prophage e14

 

2/4

2/4

1/4

 

1/4

2/4

1/3

   

1/4

 

4/4

3/4

 

Insertions

 fimA

2/2

4/4

3/4

1/4

 

1/4

   

2/3

   

3/4

  

 yeaR

     

4/4

1/4

2/4

  

3/3

   

4/4

 

 dcuC/pagP

          

3/3

2/4

   

1/1

 mgrB/yobH

   

3/4

       

3/4

   

1/1

 oppB

          

1/3

1/4

    

 clpX/lon

     

2/4

 

1/3

      

1/3

 

 cyoA

  

1/4

             
  1. X/Y: X indicates number of strains with genomic alternation, Y indicates total number of sequenced strains. A more comprehensive table detailing which genome rearrangement was identified in which replicate is provided as supplemental information (Additional file 1: Table S1)
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BMC Genomics

ISSN: 1471-2164

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