Fig. 3

Interaction between the upregulated differentially expressed gene ISG15 and its functional cellular partners. Colored nodes represent the query protein and first shell of interactors. Filled nodes are related to known or predicted 3D structures. Empty nodes correspond to proteins of unknown 3D structure. Colored lines represent known, predicted, and other interactions. The light blue line color is associated with known interactions from curated databases; the pink line represents the experimentally determined interactions; the green line represents interactions predicted from gene clusters; the red line is associated with predicted interactions according to gene fusions; the dark blue line represents predicted interactions of gene co-occurrence; yellow, black and gray lines represent other interactions