Table 1 Summary of the 25 traits
From: Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics
Phenotype | Abbreviation | # individuals (cases/controls, if applicable) | # Total SNPs | # Sig. SNPs1 | Generation year |
|---|---|---|---|---|---|
1 Neurological/Neuropsychiatric phenotypes | |||||
 Alzheimer’s disease | ALZ | 17,008 / 37,154 | 7,055,881 | 108,745 | 2013 |
 Attention deficit-hyperactivity disorder | ADHD | 1947 trio / 1947 trio & 840 / 688 | 1,230,535 | 13,120 | 2013 |
 Autism spectrum disorder | ASD | 4788 / 4788 | 1,245,864 | 15,781 | 2013 |
 Bipolar disorder | BD | 6990 / 4820 | 1,233,533 | 18,723 | 2013 |
 Major depressive disorder | MDD | 9227 / 7383 | 1,232,793 | 14,864 | 2013 |
 Schizophrenia | SCZ | 9379 / 7736 | 1,237,958 | 24,361 | 2013 |
2 Anthropometric and social traits | |||||
 Body mass index | BMI | 322,154 | 2,554,637 | 63,111 | 2015 |
 Bone mineral density (femoral neck) | FN-BMD | 32,735 | 10,586,899 | 117,114 | 2015 |
 Bone mineral density (lumbar spine) | LS-BMD | 28,498 | 10,582,866 | 120,390 | 2015 |
 Educational attainment | EDU | 293,723 | 8,146,840 | 311,622 | 2015 |
 Height | HEIGHT | 253,288 | 2,550,858 | 239,924 | 2014 |
 Waist–hip ratio | WHR | 142,762 | 2,560,788 | 38,995 | 2015 |
3 Immune-related traits | |||||
 Crohn’s disease | CD | 5956 / 14,927 | 12,276,505 | 185,729 | 2015 |
 Rheumatoid arthritis | RA | 18,136 / 49,724 | 8,747,962 | 122,601 | 2014 |
 Ulcerative colitis | UC | 6968 / 20,464 | 12,255,196 | 181,092 | 2015 |
4 Metabolic phenotypes | |||||
 Age at menarche | AAM | 182,416 | 2,441,815 | 44,202 | 2015 |
 Coronary artery disease | CAD | 22,233 / 64,762 | 2,420,360 | 41,279 | 2011 |
 Fasting glucose | FG | 46,186 | 2,470,476 | 32,818 | 2010 |
 Fasting insulin | FI | 38,238 | 2,461,105 | 30,044 | 2010 |
 High-density lipoproteins | HDL | 99,900 | 2,692,429 | 39,833 | 2010 |
 Low-density lipoproteins | LDL | 95,454 | 2,692,564 | 40,261 | 2010 |
 Total cholesterol | TC | 100,184 | 2,692,413 | 44,112 | 2010 |
 Triglycerides | TG | 96,598 | 2,692,560 | 40,574 | 2010 |
 Type 1 diabetes | T1D | 9934 / 16,956 | 2,048,237 | 45,430 | 2011 |
 Type 2 diabetes | T2D | 12,171 / 56,862 | 2,473,440 | 39,081 | 2012 |