CpG traffic lights are markers of regulatory regions in human genome

BMC Genomics

Table 1 The number of genes with significant correlation between expression and methylation

FDR-corrected p-value (significance level)	Total number of genes, which have significant correlations between gene expression and methylation
	Average methylation of promoter regions (-1000..500) (1)	Average methylation of gene bodies (+500..TTS) (2)	Methylation of CpG TL (3)	Permutation test (4)
0.001	263	186	1463	14.5
0.005	537	505	4905	15.4
0.01	764	762	7997	16.2
0.05	2038	2125	22957	21.8
0.1	3251	3401	34095	27.5

Note: for multiple testing correction the number of genes was used in (1) and (2), while the number of all CpG - gene pairs was used for the same purpose in (3) and (4). (4) Permutation test (RPKM) results: the number of genes with significant correlation between expression and methylation obtained by chance (averaged over 10 random permutations). (TTS) refers to a Transcription Termination Site

ISSN: 1471-2164