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Table 1 Major virulence-related genes in S. aureus strain, MCRF184

From: Virulence factor landscape of a Staphylococcus aureus sequence type 45 strain, MCRF184

 

Locus

Location

Enterotoxins

CKU_1443 SE

core

CKU_1636 seg

vSaβ

CKU_1637 sen

vSaβ

CKU_1638 seu

vSaβ

CKU_1639 sei

vSaβ

CKU_1640 sem

vSaβ

CKU_1641 seo

vSaβ

Exotoxins

CKU_0360 ssl1

vSaα

CKU_0361 ssl2

vSaα

CKU_0362 ssl4

vSaα

CKU_0363 ssl3

vSaα

CKU_0365 ssl5

vSaα

CKU_0366 ssl9

vSaα

CKU_0367 ssl10

vSaα

CKU_0370 ssl11

vSaα

CKU_0998 ssl12

vSaγ

CKU_0999 ssl13

vSaγ

CKU_1000 ssl14

vSaγ

Exfoliative toxin

CKU_1005 eta

vSaγ

 Alpha-hemolysin

CKU_0995 hla

vSaγ

 Beta-hemolysin

CKU_1753 hlb

фSa3

 Delta-hemolysin (RNAIII)

CKU_2494 hld

core

 Gamma-hemolysin Component

CKU_2175 hlgA

core

 Gamma-hemolysin Component

CKU_2176 hlgC

core

 Gamma-hemolysin Component

CKU_2177 hlgB

core

Adhesins

 Collagen-binding protein

CKU_2442 cna

core

 Fibronectin-adhesin

CKU_2253 fnbA

core

 Elastin adhesin

CKU_1327 ebpS

core

 Laminin-adhesin

CKU_0713 eno

core

 Fibrinogen

CKU_0723 clfA

core

 Fibrinogen

CKU_2384 clfB

core

 Fibrinogen

CKU_0989 fib

core

 Fibrinogen

CKU_0496 sdrC

core

Exoenzymes

 Serine protease

CKU_0857 htrA

core

 Serine V8 protease

CKU_0881 sspA

core

 Cysteine protease

CKU_0880 sspB

core

 Cysteine protease

CKU_0879 sspC

core

 Lipase precursor

CKU_0273 geh

core

 Lipase precursor

CKU_2426 gehC

core

 Lipase

CKU_0588 lipA

core

 Esterase

CKU_2106

core

 Hyaluronate lyase

CKU_1961 hysA2

core

 Termonuclease

CKU_1173 nucH

core

 Cell wall hydrolase

CKU_1081 lytN

core

 Zinc metalloprotease

CKU_1096

core

 Clp protease proteolytic subunit

CKU_0704 clpP

core

 Clp protease ATP binding subunit

CKU_0813 clpB

core

 Clp protease ATP binding subunit

CKU_1509 clpX

core

 Clp protease ATP binding subunit

CKU_2300 clpL

core

Phenol Soluble Modulins

 PSMα1

426,966 to 426,902

core

 PSMα2

426,870 to 426,805

core

 PSMα3

426,752 to 426,685

core

 PSMα4

426,620 to 426,559

core

 PSMβ1

CKU_1007

core

 PSMβ2

CKU_1008

core

 PSMδ

1,955,755 to 1,955,676

core

Immunomodulators

 Staphylokinase

CKU_1760 sak

ф Sa3

 Chemotaxis inhibiting protein

CKU_1758 chp

ф Sa3

 Complement inhibitor

CKU_1757

ф Sa3

 Immunoglobulin G binding protein A

CKU_0065 spa

core

 Immunoglobulin G binding protein

CKU_2174 sbi

core

 Lipoprotein like gene products

CKU_2474 lpl1

vSaα

 Lipoprotein like gene products

CKU_0373 lpl2

vSaα

 Lipoprotein like gene products

CKU_0374 lpl3

vSaα

 Lipoprotein like gene products

CKU_0375 lpl4

vSaα

 Lipoprotein like gene products

CKU_0376 lpl5

vSaα

 Lipoprotein like gene products

CKU_0377 lpl6

vSaα

 Lipoprotein like gene products

CKU_0378 lpl

vSaα

Virulence related genes

 Biofilm genes

CKU_2420 icaR

core

CKU_2421 icaA

core

CKU_2422 icaD

core

CKU_2423 icaB

core

CKU_2424 icaC

core

 Leukocidin GH

CKU_1786 lukGH

core

 Regulatory genes

S. aureus exotoxin (SaeRS)

CKU_0640 saeS

core

CKU_0641 saeR

core

 Staphylococcal accessory regulator (sarA)

CKU_0551 sarA

core

 Sigma factor B

CKU_1825 sigB

core

 Repressor of Toxins

CKU_1594 rot

core