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Table 2 Selection of differentially expressed genes in S. aureus in co-culture versus mono-culture

From: Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture

gene FCa annotation functional category
Up-regulated genes
pyrP 255.62 uracil permease metabolism
pyrC 126.35 dihydroorotase metabolism
pyrB 94.35 aspartate transcarbamoylase metabolism
pyrA 94.34 Carbamoyl-phosphate synthase small chain metabolism
carB 56.66 Carbamoyl-phosphate synthase large chain metabolism
pyrR 54.32 Bifunctional protein PyrR metabolism
pyrF 37.64 Orotidine 5′-phosphate decarboxylase metabolism
pyrE 29.69 Orotate phosphoribosyltransferase metabolism
pyrD 24.95 Dihydroorotate dehydrogenase (quinone) metabolism
argG 15.30 Argininosuccinate synthase aa metabolism
argH 12.49 Argininosuccinate lyase aa metabolism
adhE 7.64 alcohol dehydrogenase metabolism
 NWMN_1896 6.34 phage major capsid protein NM1 phage
gapR 6.00 glycolytic gap-pgk-tpi-pgm-eno operon metabolism
ndhF 5.88 NADH:menaquinone oxidoreductase (subunit 5) metabolism
pgk 5.81 glycolytic gap-pgk-tpi-pgm-eno operon metabolism
tpiA 5.67 glycolytic gap-pgk-tpi-pgm-eno operon metabolism
gapA 5.57 glycolytic gap-pgk-tpi-pgm-eno operon metabolism
pgm 5.49 glycolytic gap-pgk-tpi-pgm-eno operon metabolism
porA 5.18 Pyruvate flavodoxin ferredoxin oxidoreductase metabolism
purA 4.42 Adenylosuccinate synthetase meatbolism
 NWMN_0997 3.26 phage NM2 phage
adh1 3.17 Alcohol dehydrogenase metabolism
scdA 2.72 Iron-sulfur cluster repair protein ScdA metabolism
 NWMN_1213 2.37 Glutathione peroxidase metabolism
sodA 2.18 Superoxide dismutase metabolism
hpt 2.01 Hypoxanthine phosphoribosyltransferase metabolism
Down-regulated genes
arcB −35.81 Ornithine carbamoyltransferase aa metabolism
arcA −26.57 Arginine deiminase aa metabolism
arcD −22.97 Arginine/ornithine antiporter aa metabolism
cidA −16.67 Holin-like protein CidA cell envelope
alsD −14.89 Alpha-acetolactate decarboxylase metabolism
alsS −10.50 Alpha-acetolactate synthase metabolism
splD −10.50 Serine protease SplD virulence
putA −6.94 Proline dehygrogenase metabolism
pflB −5.92 Formate acetyltransferase metabolism
capJ −5.60 Capsular polysaccharide biosynthesis cell envelope
capI −5.59 Capsular polysaccharide biosynthesis cell envelope
trpD −5.57 Anthranilate phosphoribosyltransferase aa metabolism
lukE −5.52 leukotoxin LukE virulence
glpF −5.47 glycerol uptake facilitator transport
capN −5.46 Capsular polysaccharide biosynthesis cell envelope
hisB −5.39 Imidazoleglycerol-phosphate dehydratas metabolism
trpE −5.31 Anthranilate synthase component I aa metabolism
capL −5.25 Capsular polysaccharide biosynthesis cell envelope
capO −4.94 Capsular polysaccharide biosynthesis cell envelope
splA −3.91 Serine protease SplA virulence
splB −3.44 Serine protease SplB virulence
sarV −3.47 Staphylococcal accessory regulator signal transduction
murP −3.04 sucrose-specific PTS transporter IIBC component transport
lytN −2.35 cell wall hydrolase cell envelope
sarA −2.30 Global transcriptional regulator signal transduction
sarR −2.20 Staphylococcal accessory regulator signal transduction
purR −2.18 Pur operon repressor metabolism
gltD −2.11 Glutamate synthase, small subunit N-metabolism
gltB −2.10 Glutamate synthase, large subunit N-metabolism
  1. aFC fold change; values are the average of three replicates after normalization