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Table 4 Overrepresented Nervous System Related GO Terms Associated with Week 3 Downregulated Genes

From: Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila

GO ID

GO Term

Adjusted p-Value

Number of Genes

Fold Enrichment

GO:0007399

nervous system development

2.15E-21

72

3.9

GO:0022008

neurogenesis

1.51E-19

62

4.2

GO:0061564

axon development

9.25E-11

30

5.3

GO:0050808

synapse organization

1.13E-06

23

4.7

GO:0007611

learning or memory

3.34E-06

17

6.2

GO:0050890

cognition

3.34E-06

17

6.2

GO:0007420

brain development

1.27E-04

13

6.6

GO:0040040

thermosensory behavior

6.09E-04

6

19.3

GO:0007416

synapse assembly

1.61E-03

14

4.9

GO:0045475

locomotor rhythm

4.24E-03

9

7.6

GO:0007417

central nervous system development

5.05E-03

17

3.7

GO:0007268

chemical synaptic transmission

1.34E-02

17

3.5

  1. Adjusted p-value is based on Bonferroni correction. Number of genes refers to genes annotated with that term out of the 245 week 3 downregulated genes. Fold enrichment is compared to the relative prevalence of genes annotated with the term in the full set of Drosophila coding genes.