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Fig. 1 | BMC Genomics

Fig. 1

From: RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia

Fig. 1

Identification of expression changes upon replicative senescence or CSE exposure in pHBECs. a Experimental design. pHBECs were exposed to 1.5% CSE for 24 h at second passage, or passaged into replicative senescence. The clip art of petri dishes was depicted by our own work. b Hierarchical clustering of genes (rows) with transcriptional changes in control, senescent, and CSE conditions (columns). Values show standard deviations from average expression values per gene. c Top 10 genes upregulated from pHBECs in senescence. Bars show normalized and log-scaled mean expression scores (FPKM+ 1) ± SEM across biological replicates (n = 5), with genes ordered by average expression difference between senescence and control expression levels. d Top 10 genes downregulated in pHBECs in senescence. e Top 10 genes upregulated in pHBECs in response to CSE. f Top 10 genes downregulated in pHBECs in response to CSE

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BMC Genomics

ISSN: 1471-2164

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