RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia

Table 1 Top GSEA enriched gene sets

Gene set	Source	ES	NES	Q	Lead edge
Reactive oxygen species	Houstis et al.	0.770	2.34	0.0008	63%
Proteasome pathway	BIOCARTA	0.758	2.21	0.0012	91%
Proteasome	KEGG	0.679	2.2	0.0011	90%
ER Phagosome pathway	REACTOME	0.637	2.15	0.0010	81%
Autodegradation of CDH1 by CDH1 APC-C	REACTOME	0.641	2.15	0.0008	76%
Activation of NF-κB in B cells	REACTOME	0.631	2.14	0.0007	67%
Vif-mediated degredation of APOBEC3G	REACTOME	0.656	2.11	0.0011	72%
Cross presentation of soluble exogenous antigens	REACTOME	0.65	2.11	0.0010	70%
MYC targets	Menssen et al.	0.631	2.11	0.0010	66%
Destabilization of mRNA BY AUF1 hnRNP D0	REACTOME	0.639	2.10	0.0012	73%
Antigen processing cross presentation	REACTOME	0.594	2.09	0.0013	69%
p53 independent G1-S DNA damage checkpoint	REACTOME	0.631	2.08	0.0015	68%
CDK mediated phosphorylation and removal of CDC6	REACTOME	0.638	2.07	0.0016	71%
Regulation of ornithine decarboxylase ODC	REACTOME	0.628	2.05	0.0023	73%
SCF-β-TRCP mediated degradation of EMI1	REACTOME	0.615	2.04	0.0025	72%
MYC up	Bild et al.	0.514	2.04	0.0025	67%
Autodegradation of the E3 ubiquitin ligase COP1	REACTOME	0.634	2.04	0.0024	70%
Rapamycin response down	Peng et al.	0.488	2.02	0.0029	68%
NFE2L2 targets	Singh et al.	0.793	2.00	0.0041	90%

FDR-adjusted significance (Q), enrichment scores (ES), normalized enrichment scores (NES) are shown for MSigDB gene sets with FDR < 0.01 enrichment. Lead edge signal represents the proportion of matching genes in the early, continually rising portion of the enrichment score

ISSN: 1471-2164